Quercetin inhibits PC-3 cells

[JimmyToowong]

Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): Implications for nutritional transcriptomics and multi-target therapy - Abstract Show Comments PDF Print E-mail

[jm]

Friday, 23 July 2010

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

nooridaloii@sina.tums.ac.irThis email address is being protected from spam bots, you need Javascript enabled to view it

The aim of the present study is to evaluate the effects of quercetin, a dietary flavonoid, on human prostate adenocarcinoma PC-3 cells. Lactate dehydrogenase (LDH) release, microculture tetrazolium test (MTT assay) and real-time PCR array were employed to evaluate the effects of quercetin on cell cytotoxicity, cell proliferation and expression of various genes in PC-3 cell line. Quercetin inhibited cell proliferation and modulated the expression of genes involved in DNA repair, matrix degradation and tumor invasion, angiogenesis, apoptosis, cell cycle, metabolism and glycolysis. No cytotoxicity of quercetin on PC-3 cells was observed. Taken together, as shown by the issues of the current study, the manifold inhibitory effects of quercetin on PC-3 cells may introduce quercetin as an efficacious anticancer agent in order to be used in the future nutritional transcriptomic investigations and multi-target therapy to overcome the therapeutic impediments against prostate cancer.

{jm: Dr Snuffy Myers warns that while quercetin is indicated in men, Super-quercetin NOT indicated.}

Written by:

Noori-Daloii MR, Momeny M, Yousefi M, Shirazi FG, Yaseri M, Motamed N, Kazemialiakbar N, Hashemi S.

Reference: Med Oncol. 2010 Jul 2. Epub ahead of print.

doi: 10.1007/s12032-010-9603-3

PubMed Abstract

PMID: 20596804 Forum: Every little bit helps Title: Quercetin inhibits PC-3 cells

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