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Statins may stop bone metastases

Paul Edwards

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For a number of years Dr Mike Brown and other researchers at Manchester University have been investigating how Aarachidonic Acid (from animal fat in meat and fish) stimulates bone metastases in prostate cancer patients.


In a new study which has just been published in the British Journal of Cancer Dr Brown and his colleagues found that, when prostate cancer cells were exposed to Aarachidonic Acid, the cancer cells changed shape, becoming rounder and also sprouting projections that helped them to squeeze through the gaps in the surrounding tissues and become established in the bone marrow.  The researchers also found they were able to stop the cancer cells developing these characteristics by treating them with statins, which disrupted their ability to manufacture cholesterol.


More information about this study "Aarachidronic Acid Induction of Rho Mediated Transdothelial Migration in Prostate Cancer" can be in found in this press report


Does this trial mean that we should all add statins to our prostate cancer medications?  No -  more research is probably necessary before doing this.  Dr. Iain Frame, Director of Research at Prostate Cancer UK, commented: “It’s too early to tell conclusive results about the links between cholesterol and advanced prostate cancer from this study ....... We will watch the next stages of the research with great interest.”


Remember all drugs have side effects and may interact with other medications.  Always proceed with care, caution and consult with your doctors.


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