Enzalutamide trial in Australia for men with metastatic prostate cancer

[JimJimJimJim]

Jim Marshall (not a doctor) said ...

The ENZAMET trial is one of the two clinical trials of the drug Enzalutamide that have now begun in Australia.

 

The ENZAMET trial is for men who have metastatic prostate cancer. 

 

Men in the trial will have standard hormone therapy - an LHRH agonist such as Zoladex plus an non-steroidal anti-androgen. 

 

Half the men will use one of the current non-steroidal anti-androgens (bicalutamide, nilutamide or flutamide).

The other half will use the new non-steroidal anti-androgen Enzalutamide.

 

You cannot enter this trial if you have had your prostate cancer treated by: 

hormone treatment longer than 2 years.

 

There are more detailed rules of how you may or may not qualify available from the trial site:

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=365575

 

The hospitals offering this trial are:

 

Northern Cancer Institute - Frenchs Forest - Frenchs Forest

Royal Prince Alfred Hospital - Camperdown

Prince of Wales Hospital - Randwick

Concord Private Hospital - Concord

St Vincent's Hospital (Darlinghurst) - Darlinghurst

Wollongong Hospital - Wollongong

St George Hospital - Kogarah

Sydney Adventist Hospital - Wahroonga

Nepean Hospital - Kingswood

Port Macquarie Base Hospital - Port Macquarie

Peter MacCallum Cancer Institute - East Melbourne

St Vincent's Hospital (Melbourne) Ltd - Fitzroy

Epworth Eastern Hospital - Box Hill

Austin Health - Austin Hospital - Heidelberg

Peninsula Oncology Centre - Frankston

Royal Brisbane & Womens Hospital - Herston

Princess Alexandra Hospital - Woolloongabba

Nambour General Hospital - Nambour

Gold Coast Hospital - Southport

The Royal Adelaide Hospital - Adelaide

Flinders Medical Centre - Bedford Park

Royal Perth Hospital - Perth

Royal Hobart Hospital - Hobart

Royal Darwin Hospital - Tiwi

 

Non-steroidal anti-androgens include:

Cosudex/Casodex (bicalutamide), Anandron/ Nilandron (Nilutamide), Eulexin (Flutamide), Enzalutamide.

 

Androcur (Cyproterone), is a steroidal anti-androgen)

 

PCFA also has an excellent description of this trial at:

http://www.prostate.org.au/articleLive/pages/Australian-Organisation-Launches-Large-International-Clinical-Trials-in-Prostate-Cancer.html

 

 

... end Jim