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Overall survival is affected by where metastases are sited.

Paul Edwards

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A retrospective study (The Prognostic Importance of Metastatic Site in Men with Metastatic Castration-resistant Prostate Cancer) has been published in the journal European Urology.   The study examined data collected in the TAX 327 phase 3 trial to investigate the impact of the site of metastasis on overall survival (OS).


The study found that the pattern of spread confers a differential prognostic impact in men with metastatic castration-resistant prostate cancer:

  • Men with liver metastases with or without other metastases had the shortest median OS in the study;
  • men with lung metastases with or without other metastases had 2nd shortest median OS in the study;
  • men with bone-plus-node disease came next in terms of median OS
  • then, men with bone-only metastases; and
  • men with lymph node-only disease had the best median OS in the study.


The authors indicated that their findings needed to be validated against further data.

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