Overall survival is affected by where metastases are sited.

[Paul Edwards]

A retrospective study (The Prognostic Importance of Metastatic Site in Men with Metastatic Castration-resistant Prostate Cancer) has been published in the journal European Urology.   The study examined data collected in the TAX 327 phase 3 trial to investigate the impact of the site of metastasis on overall survival (OS).

 

The study found that the pattern of spread confers a differential prognostic impact in men with metastatic castration-resistant prostate cancer:

• Men with liver metastases with or without other metastases had the shortest median OS in the study;
• men with lung metastases with or without other metastases had 2nd shortest median OS in the study;
• men with bone-plus-node disease came next in terms of median OS
• then, men with bone-only metastases; and
• men with lymph node-only disease had the best median OS in the study.

 

The authors indicated that their findings needed to be validated against further data.