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NSAIDs use may influence PCa progression


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Hospitalization for osteoarthritis and prostate cancer specific mortality among Swedish men with prostate cancer - Abstract Show Comments PDF Print E-mail


Friday, 02 July 2010

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm 171 77, Sweden.

To examine the potential role of nonsteroidal anti-inflammatory drugs (NSAIDs) use on prostate cancer (PCa) specific mortality.

We studied the association between hospitalization for osteoarthritis prior to PCa diagnosis, as a surrogate for heavy use of NSAIDs, and PCa specific mortality in a large population of PCa patients in Sweden in 1980-2004.

Hospitalization for osteoarthritis before PCa diagnosis was associated to a lower PCa specific mortality (hazard ratio

, 0.92; 95% confidence interval [CI], 0.88-0.96), but not to the risk of death from other causes (HR, 1.03; 95% CI, 0.99-1.08). The association was stronger among younger patients and patients diagnosed in earlier calendar years.

Our data demonstrate a modestly decreased PCa specific mortality among PCa patients with hospitalization for osteoarthritis prior to PCa diagnosis, compared to those without such experience. This finding lends support to the hypothesis that NSAIDs use may influence PCa progression.

Written by:

Fang F, Valdimarsdóttir U, Mucci L, Sparén P, Ye W, Fall K. Are you the author?

Reference: Cancer Epidemiol. 2010 Jun 17. Epub ahead of print.

doi: 10.1016/j.canep.2010.05.011

PubMed Abstract

PMID: 20561833 Forum: Every little bit helps Title: NSAIDs use may influence PCa progression

This extract can be found on http://PubMed.com, and is in the public domain.

On PubMed.com there will be a link to the full paper (often $30, sometimes free).

Any highlighting (except the title) is not by the author, but by Jim Marshall.

Jim is not a doctor.

This page was found on the Advanced Prostate Cancer Community for Australian men at http://advancedprost...lia.ipbhost.com.

The link is hard to remember.

An easier way to find it is to go to JimJimJimJim.com and click on Prostate.

That's the word Jim four times, no spaces, followed by .com.

If you need other help - to perhaps find someone to talk to or a local support group:

Click on the Contact Jim button at http://JimJimJimJim.com.

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