JimmyToowong Posted July 31, 2011 Share Posted July 31, 2011 Prostate-specific antigen halving time while on neoadjuvant androgen deprivation therapy is associated with biochemical control in men treated with radiation therapy for localized prostate cancer - Abstract Show Comments PDF Print E-mail back Tuesday, 22 June 2010 Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL. To assess whether the PSA response to neoadjuvant androgen deprivation therapy (ADT) is associated with biochemical control in men treated with radiation therapy (RT) for prostate cancer. In a cohort of men treated with curative-intent RT for localized prostate cancer between 1988 and 2005, 117 men had PSA values after the first and second months of neoadjuvant ADT. Most men had intermediate-risk (45%) or high-risk (44%) disease. PSA halving time (PSAHT) was calculated by first order kinetics. Median RT dose was 76 Gy and median total duration of ADT was 4 months. Freedom from biochemical failure (FFBF, nadir + 2 definition) was analyzed by PSAHT and absolute PSA nadir before the start of RT. Median follow-up was 45 months. Four-year FFBF was 89%. Median PSAHT was 2 weeks. A faster PSA decline (PSAHT < /=2 weeks) was associated with greater FFBF (96% vs. 81% for a PSAHT >2 weeks, p = 0.0110). Those within the fastest quartile of PSAHTs (< /= 10 days) achieved a FFBF of 100%. Among high-risk patients, a PSAHT < /=2 weeks achieved a 4-yr FFBF of 93% vs. 70% for those with PSAHT >2 weeks (p = 0.0508). [Mine] Absolute PSA nadir was not associated with FFBF. On multivariable analysis, PSAHT (p = 0.0093) and Gleason score (p = 0.0320) were associated with FFBF, whereas T-stage (p = 0.7363) and initial PSA level (p = 0.9614) were not. For men treated with combined ADT and RT, PSA response to the first month of ADT may be a useful criterion for prognosis and treatment modification. Written by: Malik R, Jani AB, Liauw SL. Are you the author? Reference: Int J Radiat Oncol Biol Phys. 2010 May 24. Epub ahead of print. doi: 10.1016/j.ijrobp.2009.12.029 PubMed Abstract PMID: 20510547 Forum: Primary hormone therapy Title: In RT/ADT high risk halving time <= 2 weeks gives 93% 4-year FFBP This extract can be found on http://PubMed.com, and is in the public domain. On PubMed.com there will be a link to the full paper (often $30, sometimes free). Any highlighting (except the title) is not by the author, but by Jim Marshall. Jim is not a doctor. This page was found on the Advanced Prostate Cancer Community for Australian men at http://advancedprost...lia.ipbhost.com. The link is hard to remember. An easier way to find it is to go to JimJimJimJim.com and click on Prostate. That's the word Jim four times, no spaces, followed by .com. If you need other help - to perhaps find someone to talk to or a local support group: Click on the Contact Jim button at http://JimJimJimJim.com. Link to comment Share on other sites More sharing options...
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