Admin Posted June 2, 2019 Share Posted June 2, 2019 For metastatic castrate-resistant prostate cancer, Enzalutamide (Xtandi) works. For metastatic castrate-resistant prostate cancer, Abiraterone (Zytiga) works, but in a different way. So, perhaps using both at once might be better. Sorry. No. Dr Michael Morris reported to the ASCO (American Society of Clinical Oncology) 2019 meeting on the results of the Alliance A031201 clinical trial. On behalf of the team of doctors that did the trial, Dr Morris said: Adding abiraterone to enzalutamide does not improve OS relative to enzalutamide alone Enzalutamide/abiraterone has a modest improvement in rPFS On-treatment rPFS and OS were similar to previous studies Enzalutamide/abiraterone caused more adverse events than enzalutamide alone The current standard of care is unchanged by this study The following article is not on this site. If you click on the link below, you will be taken to a site where we do not control the content. So, please be careful about what you read there, and ask your doctor about anything you read. You may need to subscribe to the site to view the article. If it is temporarily or permanently unavailable, you may receive an error message. https://www.urotoday.com/conference-highlights/asco-2019-annual-meeting/asco-2019-prostate-cancer/112921-asco-2019-enzalutamide-versus-enzalutamide-abiraterone-and-prednisone-for-metastatic-castration-resistant-prostate-cancer-alliance-a031201.html?utm_source=newsletter_6632&utm_medium=email&utm_campaign=prostate-practice-changing-date-from-asco-2019 Link to comment Share on other sites More sharing options...
Charles (Chuck) Maack Posted June 2, 2019 Share Posted June 2, 2019 Each was developed for different actions. For know - at least in the U.S. - enzalutamide/Xtandi (a powerful antiandrogen designed to block access of androgen/testosterone to androgen receptors on cancer cells) is approved for non-metastatic castration resistant prostate cancer (nmCRPC) when PSA is rising despite, for example, failure of antiandrogens bicalutamide/Casodex, flutamide/Eulexin, or nilutamide/Nilandron. This medication is also approved for men with evident metastasis. Abiraterone/Zytiga (a powerful blocker of androgen/testosterone produced by testicular, adrenal glands, and that produced within cancer cells) is only approved when metastasis is evident. Apparently their combined use inhibits the effectiveness of the other. Not only that, but with the cost of each already quite prohibitive, it is unlikely health insurers would support combined use and cost. One would hope that abiraterone/Zytiga is eventually approved for use for men with nmCRPC since its use could be very effective to stave off metastasis when LHRH/GnRH antagonists/agonist appear to be showing failure in controlling androgen/testosterone production. Link to comment Share on other sites More sharing options...
Roscoaus2000 Posted June 3, 2019 Share Posted June 3, 2019 When Casodex stopped working for me, Enzalutamide, immediately dropped my psa to <0.01 but after 4 months I had a mild seizure, attributed to it. I was changed to Aberiterone which is just as effective in controlling my psa but has no side effects for me at all.( no change in psa for 13 months). Link to comment Share on other sites More sharing options...
Admin Posted June 3, 2019 Author Share Posted June 3, 2019 Rosco That is good news. Did you have any previous history of seizures? Link to comment Share on other sites More sharing options...
Roscoaus2000 Posted June 3, 2019 Share Posted June 3, 2019 No, none. However, in the 4 weeks prior I had two episodes whilst driving in the country when I could not remember having made a route turn and after driving several kilometres I stopped and turned back to reassure that I was on the right road. These were 4 weeks then 2 weeks before my seizure. Since changing to Aberiterone my memory is very sharp. Link to comment Share on other sites More sharing options...
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