DiRi Posted May 15, 2019 Share Posted May 15, 2019 My husband is due to see oncologist tomorrow and I'm putting together a few questions to ask. This visit is a follow up 2 months on from reducing his dose of Xtandi from 4 x 40mg tablets to 3 x 40mg tablets due to the unpleasant side effects and overwhelming fatigue and strange tingling that he would get through his body. The reduced dose has been effective in reducing the side effects to some degree so we are hoping that his PSA hasn't risen as a result. I've read about Metformin being added for those on Enzalutamide and that it may have the benefit of delaying resistance - this is one question that I will ask the oncologist. I can't help but think we are in a kind of holding pattern waiting for the Enzalutamide to stop working. If/when this happens I wonder if my husband may be offered LU-177. I know there have been mixed results, but it does sound promising (but expensive) unless on a trial? Hubby has zolodex injections every 3 months with the 120mg Xtandi daily. He has had 6 rounds of Doxetaxel and 3 sessions of radiation since diagnosis in Feb. 2017, He has "innumerable" mets in his pelvic area and one in his L3 but no lymph involvement. His pain is significant and so he takesTargin and Endone as needed. I'm guessing that if his PSA has risen the oncologist will put him back on the full 160mg dose of Xtandi and keep an eye on things. The information on this forum have been great. It has given me the ability to understand more of what the oncologist tells us and almost to know what may be next in terms of treatment, thank and any advice much appreciated. Link to comment Share on other sites More sharing options...
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