Guihan Posted January 18, 2019 Share Posted January 18, 2019 The discussion about the Brisbane Testosterone Trial has raised some questions in my mind. I am raising this as a separate issue, because my weight-loss condition (although probably ADT-induced) does not fit the usual definition of sarcopaenia. Whilst sarcopaenia is strongly associated with muscle tissue depletion, it is also associated with fat gain. I have lost both muscle and fat, and I am struggling to hang onto what I have left. These symptoms, together with my loss of appetite, seem to be more associated with the end-of-life condition named cachexia. However, I am sure that is not relevant to me, as I think I would know if I had only a couple of weeks to live. Bear with me while I summarize my situation, then I will seek the experience of other members about how to answer some questions. History Radical prostatectomy December 2003. PSA began to rise August 2006. Started ADT (Zoladex) September 2007. After three subsequent PSA rises were successfully suppressed, PSA was driven too low to register in July 2011, and has remained below recordable levels ever since. I have now been on ADT for 11 years, and have had a total of 24 Zoladex implants. CT scan of my torso revealed no sign of disease. What I Would Like to Know The discussion about ADT-induced sarcopaenia has prompted me to ask you learned gentlemen for the benefit of your experience in relation to these questions: It has been pointed out to me that long-term ADT can permanently disable the function of the testes. When my doctor ordered a test of my testosterone level, it came back as "Too low to register". How can I determine if my testes are still functioning? My PSA is also still too low to record. Even if I stopped ADT now, it could be years before I see any PSA reading. If my testes are already permanently dysfunctional, my testosterone-deprived muscles are unlikely to wait that long for nourishment. Should I begin testosterone therapy now? The Brisbane trial is using oral testosterone because it metabolises in the liver, and delivers useful muscle nourishment without feeding any prostate cancer. It seems that oral testosterone would not be suitable in my case because it depletes fat levels (and I have no fat to spare). What form of testosterone would be most apt in my case? Because I have not been able to measure any PSA for many years, it seems possible that my prostate cancer has now vanished. How can I find out if I still have it? Link to comment Share on other sites More sharing options...
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