JimmyToowong Posted July 31, 2011 Share Posted July 31, 2011 Prostate Cancer and Prostatic Diseases (2011) 14, 177–183; doi:10.1038/pcan.2011.7; published online 15 March 2011 Mortality following bone metastasis and skeletal-related events among men with prostate cancer: a population-based analysis of US Medicare beneficiaries, 1999–2006 N Sathiakumar1, E Delzell1, M A Morrisey1, C Falkson2, M Yong3, V Chia3, J Blackburn1, T Arora1 and M L Kilgore1 Correspondence: Dr N Sathiakumar, School of Public Health, University of Alabama at Birmingham, 1665 University Boulvard, Birmingham, AL 35294, USA. E-mail: nalini@uab.edu Received 6 December 2010; Revised 31 January 2011; Accepted 1 February 2011; Published online 15 March 2011. Abstract Information on the impact of bone metastasis and skeletal-related events (SREs) on mortality among prostate cancer patients is limited. Using the linked Surveillance, Epidemiology and End Results (SEER)-Medicare database, we identified men aged 65 years or older diagnosed with prostate cancer between July 1 1999 and December 31 2005 and followed to determine deaths through December 31 2006. We classified subjects as having bone metastasis and SREs as indicated by Medicare claims. Using Cox regression, we estimated mortality hazards ratios (HR) among men with bone metastasis with or without SRE, compared with men without bone metastasis. Among 126?978 men with prostate cancer (median follow-up, 3.3 years), 9746 (7.7%) had bone metastasis at prostate cancer diagnosis (1.7%) or during follow-up (5.9%). SREs occurred in 4296 (44%) men with bone metastasis. HRs for risk of death were 6.6 (95% CI=6.4–6.9) and 10.2 (95% CI=9.8–10.7), respectively, for men with bone metastasis but no SRE and for men with bone metastasis plus SRE, compared with men without bone metastasis. Bone metastasis was associated with mortality among prostate cancer patients. This association appeared to be stronger for bone metastasis plus SRE than for bone metastasis without SRE.PMID: 21403668 Forum: Metastatic prostate cancer Title: Skeletal-related events (SREs), metastasis and survival This extract can be found on http://PubMed.com, and is in the public domain. On PubMed.com there will be a link to the full paper (often $30, sometimes free). Any highlighting (except the title) is not by the author, but by Jim Marshall. Jim is not a doctor. This page was found on the Advanced Prostate Cancer Community for Australian men at http://advancedprost...lia.ipbhost.com. The link is hard to remember. An easier way to find it is to go to JimJimJimJim.com and click on Prostate. That's the word Jim four times, no spaces, followed by .com. If you need other help - to perhaps find someone to talk to or a local support group: Click on the Contact Jim button at http://JimJimJimJim.com. Link to comment Share on other sites More sharing options...
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