MBarry Posted April 25, 2018 Share Posted April 25, 2018 Hi. I was diagnosed at age 57 with stage 4 Metastatic PC in Nov 2015 with widespread bone mets and mets to lymph nodes Unusually the original tumor was never found and hence I do not have Gleason score and have had no Prostate surgery. I have been through Bicalutamide (Casodex), Chemo (Docataxel), Zytiga and Xtandi treatments. All have worked for a while and then failed. Recently I was confirmed with BRCA2 gene mutation, both germline and in a sample tumor. I was able to gain access to a PARP inhibitor Rucaoarib,but unfortunately this also seems to have had a brief positive response and is now failing after 3 months. My choices seem to be try another PARP inhibitor or move to a Platinum based chemo drug Carboplatin. I really don't want Chemo again if I can help it as I had a pretty rough time on Docataxel. Does anyone know if another PARP inhibitor can give different results or are they all fairly similar? There have been some fantastic results reported with Olapatib and MCRPC. I was really hoping I might get similar from the Rucaparib, but you know, the roller coaster of ups and downs continues.? I think my MO, who is fantastic, is leaning towards Carboplatin, but would love to hear from anyone who is receiving treatments who s BRCA positive. Other drugs I am on currently apart from pain killers are Zoladex 3 monthly, Vit D monthly, Zometa infusion monthly.I have had extensive radiation therapy over the past 2 years for pain relief with good results. Thanks for reading this far and best wishes to everyone on the site. Martin Link to comment Share on other sites More sharing options...
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