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Radiation complications often improve over time

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Healing of late endoscopic changes in the rectum between 12 and 65 months after external beam radiotherapy - Abstract

Wed, 23 March 2011

Department of Radiotherapy and Radiobiology, Vienna General Hospital, University of Vienna Medical School, Vienna, Austria.


To evaluate the time course of late rectal mucosal changes after prostate cancer radiotherapy (RT).

A rectosigmoidoscopy was performed at 12, 24, and 65 months after RT in 20 patients. Rectal mucosal changes (telangiectasia, congested mucosa, ulceration, stricture, and necrosis) were scored and documented according to the Vienna Rectoscopy Score (VRS, score 0-3).

VRS of 0 and 3, were found in 20% of patients (n = 4) and 5% of patients (n = 1), respectively at all time points. A shift of the VRS from 2 to 1 was found with incidence rates of 60% at 12 months and 20% at 65 months, which is equivalent to an improvement rate of 67%. Laser coagulation was required in 3 patients (15%) with rectal bleeding due to telangiectasia grade ?2.

Late rectal mucosal changes are frequent after pelvic RT. Generally only the incidence rates corresponding to the initial diagnosis of the complications, independent of subsequent recovery, are reported. The results reported in the present study show that complications often improve over time. Hence, the usual reports of complication rates overestimate the proportion of patients presenting with side effects of certain grades.

Written by:

Goldner G, Pötter R, Kranz A, Bluhm A, Dörr W.

Reference: Strahlenther Onkol. 2011 Mar;187(3):202-205.

doi: 10.1007/s00066-010-2211-5

PubMed Abstract

PMID: 21347635 Forum: Other prostate cancer topics including radiation Title: Radiation complications often improve over time

This extract can be found on http://PubMed.com, and is in the public domain.

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