Jump to content

Avoiding weight gain limits recurrence after prostatectomy

Recommended Posts

Weight gain is associated with an increased risk of prostate cancer recurrence after prostatectomy in the PSA era - Abstract

Tuesday, 15 March 2011

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health.

While obesity at time of prostatectomy has been associated with prostate cancer recurrence, it is unknown whether obesity before or after surgery, or weight change from the years prior to surgery to after surgery is associated with recurrence. Thus, we examined the influence of obesity and weight change on recurrence after prostatectomy.

We conducted a retrospective cohort study of 1,337 men with clinically-localized prostate cancer who underwent prostatectomy performed during 1993-2006 by the same surgeon. Men self-reported weight and physical activity at 5 years before and 1 year after surgery on a survey during follow-up. Mean follow up was 7.3 years. We estimated multivariable-adjusted hazard ratios of prostate cancer recurrence comparing obesity at 5 years before and at 1 year after surgery with normal weight, and a gain of >2.2 kg from 5 years before to 1 year after surgery with stable weight.

During 9,797 person years of follow-up, 102 men recurred. Compared with men who had stable weight, those whose weight increased >2.2 kg had twice the recurrence risk (HR=1.94, 95% CI 1.14-3.32) after taking into account age, pathological stage and grade, and other characteristics. The HR of recurrence was 1.20 (95% CI 0.64-2.23) and 1.72 (95% CI 0.94-3.14) comparing obesity at 5 years before and at 1 year after surgery, respectively, with normal weight. Physical activity (?5 hrs/wk) did not attenuate risk in men who gained >2.2 kg.

By avoiding weight gain, men with prostate cancer may both prevent recurrence and improve overall well-being.

Written by:

Joshu CE, Mondul AM, Menke A, Meinhold CL, Han M, Humphreys E, Freedland SJ, Walsh PC, Platz EA.

Reference: Cancer Prev Res (Phila). 2011 Feb 16. Epub ahead of print.

doi: 10.1158/1940-6207.CAPR-10-0257

PubMed Abstract

PMID: 21325564 Forum: Other prostate cancer topics including radiation Title: Avoiding weight gain limits recurrence after prostatectomy

This extract can be found on http://PubMed.com, and is in the public domain.

On PubMed.com there will be a link to the full paper (often $30, sometimes free).

Any highlighting (except the title) is not by the author, but by Jim Marshall.

Jim is not a doctor.

This page was found on the Advanced Prostate Cancer Community for Australian men at http://advancedprost...lia.ipbhost.com.

The link is hard to remember.

An easier way to find it is to go to JimJimJimJim.com and click on Prostate.

That's the word Jim four times, no spaces, followed by .com.

If you need other help - to perhaps find someone to talk to or a local support group:

Click on the Contact Jim button at http://JimJimJimJim.com.

Link to comment
Share on other sites


This topic is now archived and is closed to further replies.

  • Create New...