Charles (Chuck) Maack Posted November 10, 2017 Share Posted November 10, 2017 Interesting information for those prescribed enzalutamide (Xtandi) as part of their androgen deprivation (ADT) regimen and appearing to show little effectiveness. There are factors that resist enzalutamide effectiveness but with the addition of Metformin that resistance can be reversed and sensitivity of enzalutamide activity restored. http://tinyurl.com/y8u7dbkm By using C4-2, CWR22Rv1 and LNCaP cell lines, as well as mice bearing CWR22Rv1 xenografts treated with either enzalutamide or metformin alone or in combination, we demonstrated that metformin is capable of reversing enzalutamide resistance and restores sensitivity of CWR22Rv1 xenografts to enzalutamide. We showed that metformin alleviated resistance to enzalutamide by inhibiting EMT. Furthermore, based on the effect of metformin on the activation of STAT3 and expression of TGF-beta 1, we propose that metformin exerts its effects by targeting the TGF-beta 1/STAT3 axis." According to the news editors, the research concluded: "These findings suggest that combination of metformin with enzalutamide could be a more efficacious therapeutic strategy for the treatment of castration-resistant prostate cancer." DISCLAIMER: Please recognize that I am not a Medical Doctor. Rather, as a medical detective, I have been an avid student researching and studying prostate cancer as a survivor and continuing patient since 1992. I have dedicated my retirement years to continued research and study in order to serve as an advocate for prostate cancer awareness, and, from an activist patient’s viewpoint, to voluntarily help patients, caregivers, and others interested develop an understanding of prostate cancer, its treatment options, and the treatment of the side effects that often accompany treatment. There is absolutely no charge for my mentoring – I provide this free service as one who has been there and hoping to make your journey one with better understanding and knowledge than was available to me when I was diagnosed so many years ago. IMPORTANTLY, readers of this paper must understand that the comments or recommendations I make are not intended to be the procedure to blindly follow; rather, they are to be reviewed as my opinion, then used for further personal research, study, and subsequent discussion with the medical professional/physician providing your prostate cancer care. Charles (Chuck) Maack - Prostate Cancer Patient/Activist/Reduced Activity as Mentor (Because of age related health issues, had to limit what had been worldwide daily mentoring) (A mentor should be someone who offers courtesy, professionalism, respect, wisdom, knowledge, and support to help you achieve your goals; would that I succeed) Always as close as the other end of your computer to help address any prostate cancer concerns. "What you leave behind is not what is engraved in stone monuments, but what is woven into the lives of others." “A good character is the best tombstone. Those who loved you will remember. Carve your name on hearts, not on marble.” “Sepius Exertus, Semper Paratus, Semper Fortis, Semper Fidelis, Fraters Infinitas” “Often tested, Always Prepared, Always Courageous, Always Faithful, Brothers Forever" Recipient 2008 Us TOO Intl., Inc., Prostate Education & Support Network 1st “Edward C. Kaps Hope Award” Recipient 2012 Prostate Cancer Research Institute (PCRI) “Harry Pinchot Award” Recipient 2016 Us TOO Intl., Inc. Certificate for 20 Years Dedication/Inspiration Email: firstname.lastname@example.org My website http://www.theprostateadvocate.com Link to comment Share on other sites More sharing options...
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