Barree Posted October 9, 2017 Share Posted October 9, 2017 Radium-223 Radiographic Response: From the Desk of the Associate Editor URO TodayCommentary by Andrew Armstrong, MD,ScM, FACP, USA This is a very brief summary of the take away from this study - Follow the link at the bottom of the article for complete details Radium-223 is best used early, before extensive soft tissue metastases occurs, and before the risk of spinal cord compression increases. (Note: Soft tissue disease is not being treated whilst Radium-223 therapy is being administered, it is not effective against soft tissue tumors.) For this reason when being treated with Radium 223 - concurrent use of systemic therapies should be considered in patients with soft tumors/extra-skeletal metastases. Ongoing trials of Radium-223 with enzalutamide, abiraterone, sipuleucel-T, atezolizumab, PARP inhibitors, docetaxel, and other combinations should clarify the optimal combination approaches to controlling bone and soft tissue/visceral metastases. Patients should be followed carefully for pain flare and are likely to need opiate dose titration during therapy. Concurrent care by a palliative care specialist should be strongly considered, given the life expectancy and palliative needs for these patients. Written by: Andrew Armstrong, MD, Dr. Armstrong is Associate Professor of Medicine, Surgery, Pharmacology and Cancer Biology and Associate Director of the Duke Cancer Institute Genitourinary Clinical Research Program Full Text :- Imaging response during therapy with radium-223 for castration-resistant prostate cancer with bone metastases—analysis of an international multicenter database https://tinyurl.com/yba4zcpv Link to comment Share on other sites More sharing options...
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