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Diabetics have higher GS at diagnosis


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Does diabetes mellitus increase the risk of high-grade prostate cancer in patients undergoing radical prostatectomy? - Abstract

Thursday, 11 November 2010

Department of Urology, San Raffaele Hospital, Vita-Salute University, Milan, Italy.

The objective was to test the hypothesis that in patients with prostate cancer undergoing radical prostatectomy (RP), diabetic patients are at a higher risk of harboring a high-grade tumor than non-diabetic patients. We examined 2060 consecutive men who underwent RP between 2001 and 2009. Of them, 7.1% had type 2 diabetes mellitus (DM). A high-grade tumor was defined as having a Gleason score ? 8. Univariable and multivariable logistic regression analyses were used to test the relationship between type 2 DM and high-grade tumor. Mean patient age was 64 years (range: 45-85). Mean total PSA level was 9?ng?ml(-1) (range: 1-89.5). A significantly higher percentage of diabetic patients had high-grade tumor on biopsy (16.3 vs 7.6%; P=0.001) and on RP specimen (21.1 vs 11.7%; P=0.001) in comparison with non-diabetic patients. In multivariable analyses, DM was an independent predictor of high-grade tumor on biopsy (odds ratio=2.31, P=0.001) and on final pathological specimen (odds ratio=2.22, P=0.002). In patients undergoing RP, those with type 2 DM had a higher risk of harboring a poorly differentiated tumor on final pathological examination.

Written by:

Abdollah F, Briganti A, Suardi N, Gallina A, Capitanio U, Salonia A, Cestari A, Guazzoni G, Rigatti P, Montorsi F.

Reference: Prostate Cancer Prostatic Dis. 2010 Oct 19. Epub ahead of print.

doi: 10.1038/pcan.2010.41

PMID: 20956995 Forum: Primary hormone therapy Title: Diabetics have higher GS at diagnosis


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