Paul Edwards Posted August 1, 2015 Share Posted August 1, 2015 JNJ-56021927 (formerly known as ARN-509) is an androgen receptor antagonist. Some prostate cancer cells require androgens for growth. JNJ-56021927 prevent androgens from binding to the prostate cancer cells’ androgen receptors. JNJ-56021927 is not as advanced in its development as enzalutamide (Brand name Xtandi). Results from initial clinical trials suggest that JNJ-56021927 may be more potent and effective than enzalutamide. A Phase 3 Randomized, Placebo-controlled Double-blind Study of JNJ-56021927 in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Subjects With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer is being conducted. Details of this trial can be found by clicking on this link: https://clinicaltrials.gov/ct2/show/NCT02257736 This clinical trial is being conducted at a number of hospitals in most Australian states. I am aware that the Royal Melbourne Hospital has commenced recruitment of patients for this trial. I'm not aware of the recruitment status of the other Australian sites but I expect that these sites will commence recruitment shortly, if they are not already doing so. There will be 2 arms of the trial. Patients on the 1st arm will receive Abiraterone, Prednisone and JNJ-56021927. Patients on the 2nd arm will receive Abiraterone, Prednisone and a placebo. Link to comment Share on other sites More sharing options...
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