Jump to content

Add Avodart (dutasteride) to Ketoconazole?


Recommended Posts

Activity of dutasteride plus ketoconazole in castration-refractory prostate cancer after progression on ketoconazole alone. [Clin Genitourin Cancer. 2009]

Dana-Farber Cancer Institute, Boston, MA, USA. osartor@tulane.edu


BACKGROUND: Ketoconazole is a commonly used secondary hormonal therapy in castration-refractory prostate cancer (CRPC), but disease progression inevitably occurs. Both prostatic and metastatic lesions in patients with CRPC overexpress 5-alpha reductase (SRDA5) type I. We hypothesized that SRDA5 inhibition in combination with ketoconazole would mitigate progression after treatment with ketoconazole alone.

PATIENTS AND METHODS: A total of 10 patients with CRPC with progression after ketoconazole treatment were treated with a combination of ketoconazole plus dutasteride 0.5 mg/day, a dual SRDA5 inhibitor.

RESULTS: After dutasteride addition, 8 (80%) of the 10 patients had varying degrees of prostate-specific antigen (PSA) decline relative to baseline. Median progression-free survival after dutasteride addition was 4.9 months (range, 2.7+ to 9.8 months); no patient had a >OR= 50% PSA decline.

CONCLUSION: We conclude that dutasteride added to ketoconazole at the time progression might prolong time to PSA progression in patients with CRPC.


Excerpted from Activity of dutasteride plus ketoconazole in castr... [Clin Genitourin Cancer. 2009] - PubMed result

PMID: 19815488 Forum: Castrate Resistant Prostate Cancer Title: Add Avodart (dutasteride) to Ketoconazole?

This extract can be found on http://PubMed.com, and is in the public domain.

On PubMed.com there will be a link to the full paper (often $30, sometimes free).

Any highlighting (except the title) is not by the author, but by Jim Marshall.

Jim is not a doctor.

This page was found on the Advanced Prostate Cancer Community for Australian men at http://advancedprost...lia.ipbhost.com.

The link is hard to remember.

An easier way to find it is to go to JimJimJimJim.com and click on Prostate.

That's the word Jim four times, no spaces, followed by .com.

If you need other help - to perhaps find someone to talk to or a local support group:

Click on the Contact Jim button at http://JimJimJimJim.com.

Link to comment
Share on other sites


This topic is now archived and is closed to further replies.

  • Create New...