Add Avodart (dutasteride) to Ketoconazole?

[JimmyToowong]

Activity of dutasteride plus ketoconazole in castration-refractory prostate cancer after progression on ketoconazole alone. [Clin Genitourin Cancer. 2009]

Dana-Farber Cancer Institute, Boston, MA, USA. osartor@tulane.edu

Abstract

BACKGROUND: Ketoconazole is a commonly used secondary hormonal therapy in castration-refractory prostate cancer (CRPC), but disease progression inevitably occurs. Both prostatic and metastatic lesions in patients with CRPC overexpress 5-alpha reductase (SRDA5) type I. We hypothesized that SRDA5 inhibition in combination with ketoconazole would mitigate progression after treatment with ketoconazole alone.

PATIENTS AND METHODS: A total of 10 patients with CRPC with progression after ketoconazole treatment were treated with a combination of ketoconazole plus dutasteride 0.5 mg/day, a dual SRDA5 inhibitor.

RESULTS: After dutasteride addition, 8 (80%) of the 10 patients had varying degrees of prostate-specific antigen (PSA) decline relative to baseline. Median progression-free survival after dutasteride addition was 4.9 months (range, 2.7+ to 9.8 months); no patient had a >OR= 50% PSA decline.

CONCLUSION: We conclude that dutasteride added to ketoconazole at the time progression might prolong time to PSA progression in patients with CRPC.

References

Excerpted from Activity of dutasteride plus ketoconazole in castr... [Clin Genitourin Cancer. 2009] - PubMed result

PMID: 19815488 Forum: Castrate Resistant Prostate Cancer Title: Add Avodart (dutasteride) to Ketoconazole?

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