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Mice with PCa last longer wit tomato powder frm tomato paste

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A Dietary Tomato Supplement Prevents Prostate Cancer in TRAMP Mice. - Abstract

Monday, 06 September 2010

1Oncology and Neuroscience, Aging Research Center.

The transgenic adenocarcinoma of the mouse prostate (TRAMP) is a model for progressive prostate cancer (PCa) that mirrors the stages of the human form. In this study we investigated the effects of a diet enriched with 10% tomato powder from heat-processed paste from whole cherry tomatoes, including seeds and skins, on survival, tumorigenesis and progression of PCa, and on the antioxidant and inflammatory status of TRAMP mice.This diet significantly increased overall survival rate (from 11% to 67%), delayed progression from Prostatic Intraepithelial Neoplasia (PIN) to adenocarcinoma (ADK) (79.2% vs 9.4% of adenocarcinomatous prostatic area at 25 weeks of age), and decreased the incidence of poorly differentiated carcinoma (PD) from 56% to 17%.Biochemical data disclosed an increase in serum antioxidant activity, and a reduction of serum inflammation/angiogenesis biomarkers of particular importance in prostate carcinogenesis.

Written by:

Pannellini T, Iezzi M, Liberatore M, Sabatini F, Iacobelli S, Rossi C, Alberti S, Di Ilio C, Vitaglione P, Fogliano V, Piantelli M.

Reference: Cancer Prev Res (Phila Pa). 2010 Aug 17. [Epub ahead of print]

doi: 10.1158/1940-6207.CAPR-09-0237

PubMed Abstract

PMID: 20716635 Forum: Other prostate cancer topics including radiation Title: Mice with PCa last longer with tomato powder from tomato paste

This extract can be found on http://PubMed.com, and is in the public domain.

On PubMed.com there will be a link to the full paper (often $30, sometimes free).

Any highlighting (except the title) is not by the author, but by Jim Marshall.

Jim is not a doctor.

This page was found on the Advanced Prostate Cancer Community for Australian men at http://advancedprost...lia.ipbhost.com.

The link is hard to remember.

An easier way to find it is to go to JimJimJimJim.com and click on Prostate.

That's the word Jim four times, no spaces, followed by .com.

If you need other help - to perhaps find someone to talk to or a local support group:

Click on the Contact Jim button at http://JimJimJimJim.com.

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