Zoledronic acid schedules from months to 6 months equivalent

[JimmyToowong]

Urol Int. 2010 Jul 14. [Epub ahead of print]

Titration of Dosage for the Protective Effect of Zoledronic Acid on Bone Loss in Patients Submitted to Androgen Deprivation Therapy due to Prostate Cancer: A Prospective Open-Label Study.

Rodrigues P, Meler A, Hering F.

Hospital Santa Helena of São Paulo, São Paulo, Brazil.

Abstract

Background: Bisphosphonates were incorporated as agents for the long-term effect of androgen deprivation therapy (ADT) but no comparative study was established for the optimal schedule for bone preservation. Methods: Ninety-five consecutive prostate cancer patients submitted to radical retropubic prostatectomy were recruited. At rising PSA they were prospectively enrolled in nonrandomized fashion and grouped to receive no treatment (21 - control group), and monthly (17), bi-monthly (15), tri-monthly (19) or semestral [6 monthly] (15) 4 mg zoledronic acid infusions. The patients were followed to a minimum of 30 months after receiving ADT by LHRH agonists. Bone mineral density (BMD) was measured every 6 months in all 5 studied groups in order to compare the effect of each regimen to nontreatment. Tukey-Kramer and Scheffe's tests were used.

RESULTS: The control group showed an impressive BMD loss throughout the study period. The 4 groups treated with zoledronic acid infusions showed increased BMD in the lumbar area on periodical densitometry and no statistical differences could be established among the 4 studied schedules. Different individual patterns of decreasing (control) or increasing (treated) BMD could be seen along the study as measured by bone densitometry.

CONCLUSIONS: Zoledronic acid treatment promoted effective osseous protection against the natural demineralization process in patients with prostate cancer recurrence submitted to ADT. Copyright © 2010 S. Karger AG, Basel.

PMID: 20628233 Forum: Other prostate cancer topics including radiation Title: Zoledronic acid schedules from monthly to 6 monthly equivalent

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