Admin Posted July 17, 2013 Share Posted July 17, 2013 Jim Marshall (not a doctor) said ... These researchers looked at fatty acids from different sources. They found that fatty acids from fish protected against prostate cancer, especially metastatic prostate cancer. They found that fatty acids from plant sources did not have this protective effect. Their results for fish-oil supplement use were weaker than those for EPA + DHA from diet and supplements combined, which suggests that fish may contain additional protective agents not contained in fish-oil supplements, such as vitamin D and retinol. ... end Jim Am J Clin Nutr. 2004 Jul;80(1):204-16. Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. Leitzmann MF, Stampfer MJ, Michaud DS, Augustsson K, Colditz GC, Willett WC, Giovannucci EL. Source Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. leitzmann@mail.nih.gov Abstract BACKGROUND: Laboratory studies have shown that n-3 fatty acids inhibit and n-6 fatty acids stimulate prostate tumor growth, but whether the dietary intake of these fatty acids affects prostate cancer risk in humans remains unclear. OBJECTIVE: We prospectively evaluated the association between intakes of alpha-linolenic (ALA; 18:3n-3), eicosapentaenoic (EPA; 20:5n-3), docosahexaenoic (DHA; 22:6n-3), linoleic (LA; 18:2n-6), and arachidonic (AA; 20:4n-6) acids and prostate cancer risk. DESIGN: A cohort of 47 866 US men aged 40-75 y with no cancer history in 1986 was followed for 14 y. RESULTS: During follow-up, 2965 new cases of total prostate cancer were ascertained, 448 of which were advanced prostate cancer. ALA intake was unrelated to the risk of total prostate cancer. In contrast, the multivariate relative risks (RRs) of advanced prostate cancer from comparisons of extreme quintiles of ALA from nonanimal sources and ALA from meat and dairy sources were 2.02 (95% CI: 1.35, 3.03) and 1.53 (0.88, 2.66), respectively. EPA and DHA intakes were related to lower prostate cancer risk. The multivariate RRs of total and advanced prostate cancer from comparisons of extreme quintiles of the combination of EPA and DHA were 0.89 (0.77, 1.04) and 0.74 (0.49, 1.08), respectively. LA and AA intakes were unrelated to the risk of prostate cancer. The multivariate RR of advanced prostate cancer from a comparison of extreme quintiles of the ratio of LA to ALA was 0.62 (0.45, 0.86). CONCLUSIONS: Increased dietary intakes of ALA may increase the risk of advanced prostate cancer. In contrast, EPA and DHA intakes may reduce the risk of total and advanced prostate cancer. PMID: 15213050 Full paper free: http://ajcn.nutrition.org/content/80/1/204.long From the full paper: Our results for fish-oil supplement use were weaker than those for EPA + DHA from diet and supplements combined, which suggests that fish may contain additional protective agents not contained in fish-oil supplements, such as vitamin D and retinol. This extract can be found on http://PubMed.com, and is in the public domain. On PubMed.com there will be a link to the full paper (often $30, sometimes free). Any highlighting (except the title) is not by the author, but by Jim Marshall. Jim is not a doctor. Link to comment Share on other sites More sharing options...
Recommended Posts
Archived
This topic is now archived and is closed to further replies.