JimJimJimJim Posted September 20, 2012 Share Posted September 20, 2012 Jim Marshall (not a doctor) said ... One scenario for advanced prostate cancer treatment is: Primary treatment - one or more of: surgery, radiation, primary hormone therapy (ADT)) Recurrence treatment - one or more of: radiation, primary hormone therapy (ADT), secondary hormone treatment Castrate resistant treatment: chemotherapy Chemotherapy resistant treatment other agents like Zytiga (abiraterone acetate), not yet PBS approved in Australia. (This is just one scenario. There are many different prostate cancer treatments. There are many different combinations and sequences of these treatments.) Chemotherapy The first chemotherapy used is often Taxotere (docetaxel). It gives some patients some extra survival time with a reasonable quality of life for most of them. If you do not respond to docetaxel initially, or it fails after some time, Jevtana (Cabazitaxel) can be used. It too gives some patients some extra survival time with a reasonable quality of life for most of them. Another chemotherapy agent sometime used is Novantrone/DHAD (Mitoxantrone (sometimes spelt mitozantrone)). It has not been reported to extend life, but can give many patients a greater quality of life. [Addendum: Novantrone/DHAD (Mitoxantrone (sometimes spelt mitozantrone)) did extend life significantly if given with Combined Hormone Blockade (CAB) to men with locally advanced disease as the first treatment in a small study of 38 men. CAB = an LHRH agonist like Lucrin or Zoladex + an antiandrogen like Cosudex or Flutamide.] We previously reported that Jevtana (Cabazitaxel) is not on available to most men in Australia. Thanks to Euan Perry's vigilance on drug approvals, we can now report that Jevtana (Cabazitaxel) is now available in Australia on the PBS (Pharmaceutical Benefits Scheme). The conditions for your doctor's prescribing this are listed below. ... end Jim From the PBS website: Jevtana (Cabazitaxel) may be prescribed for: Treatment, in combination with prednisone or prednisolone, of castration resistant metastatic carcinoma of the prostate in a patient who has failed treatment with docetaxel due to resistance or intolerance and has a WHO performance status of 2 or less. Note Patients who have received PBS-subsidised cabazitaxel are not eligible for PBS-subsidised docetaxel. Patients who have progressive disease on cabazitaxel are no longer eligible for PBS-subsidised cabazitaxel. LHRH agonists include Zoladex (Goserelin), Lupron (leuprorelin), Eligard (leuprolide), Lucrin (leuprorelin acetate), Suprefact (buserelin), Suprecor (buserelin), Synarel (nafarelin), histrelin (Supprelin), Suprelorin (deslorelin), Ovuplant(deslorelin), Triptorelin Antiandrogens used in primary hormone therapy include Cosudex/Casodex (bicalutamide), Anandron (Nilutamide), Nilandron(Nilutamide), Eulexin (Flutamide), all nonsteroidal, and Androcur (Cyproterone, a steroid), Link to comment Share on other sites More sharing options...
Nev Black Posted September 20, 2012 Share Posted September 20, 2012 When hormone therapy fails (ADT) and you move on to Taxotere ect. do you remain on ADT during the Chemotherapy Treatment? Nev Link to comment Share on other sites More sharing options...
JimJimJimJim Posted September 20, 2012 Author Share Posted September 20, 2012 USA medical oncologist Stephen Strum is quite clear on this. You should continue. In this paper, Lee and colleagues found in a small sample that it did give you longer survival, but not significantly: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=64&abstractID=20280 If you wish a lot more information, try http://www.hrpca.org/FAQ.htm. Link to comment Share on other sites More sharing options...
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