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Hormone treatment before radiation or after recurrence - no added heart risk


JimJimJimJim

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JimJimJimJim

Jim Marshall (not a doctor) said ...

There is some concern by doctors that hormone therapy may possibly increase your risk of dying of heart disease.

But now, after 10 years of follow up

  • 6 months of hormone treatment before radiotherapy did not increase your risk of dying of heart disease; and
  • if you added more hormone therapy when your disease recurred, that did not increase your risk; and
  • you were not at any greater risk if you were over 65 year old.

... end Jim

Oncology. 2012;82(1):56-8. Epub 2012 Feb 4.

Androgen deprivation therapy for prostate cancer does not increase cardiovascular mortality in the long term.

Wilcox C, Kautto A, Steigler A, Denham JW.

Source

School of Medicine and Public Health, The University of Newcastle, Callaghan, N.S.W., Australia.

Abstract

OBJECTIVE:

To determine if 6 months of neo-adjuvant androgen deprivation is associated with the long-term risk of cardiac mortality.

METHODS:

In the TROG 96.01 trial, 802 men with locally advanced prostate cancer were randomized to radiotherapy either alone or with 3 or 6 months of neo-adjuvant androgen deprivation therapy (NADT). Competing risk methodology was used to derive the cumulative incidence of fatal cardiac events.

RESULTS:

At 10 years, the cumulative incidence of fatal cardiac events for the radiation therapy alone arm was 7.54% compared to a nonstatistically significant decreased incidence of 6.44% in the 6-month NADT arm (p = 0.65). Men aged over 65 years were not at an increased risk. Additional androgen deprivation therapy given as secondary treatment at tumor progression did not confer an increased risk.

CONCLUSION:

These data suggest that fatal cardiac events are not more common in men receiving up to 6 months of NADT.

Copyright © 2012 S. Karger AG, Basel.

PMID: 22310055

This extract can be found on http://PubMed.com, and is in the public domain.

On PubMed.com there will be a link to the full paper (often $30, sometimes free).

Any highlighting (except the title) is not by the author, but by Jim Marshall.

Jim is not a doctor.

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Geoff Buttfield

Interesting, But doesn't rule out concerns for longer term ADT. Does anyone only get 6 months anymore?

Geoff B.

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JimJimJimJim

Geoff

Correct - does not rule out long term concerns completely.

But also using ADT after recurrence was not a heart problem, so it more than 6 months in total was not a problem.

Jim

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