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Docetaxel: clinic vs clinical trial response rates


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A review of the patterns of docetaxel use for hormone-resistant prostate cancer at the Princess Margaret Hospital -

Monday, 03 May 2010

Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, ON.

Based on the tax 327 phase iii trial, docetaxel-based chemotherapy is the standard first-line treatment for hormone-resistant prostate cancer (hrpc); however, there is some heterogeneity in the use of this agent in routine clinical practice. The aim of the present study was to examine the patterns of docetaxel use in routine clinical practice at our institution and to compare them with docetaxel use in the tax 327 clinical trial.

We conducted a retrospective chart review of hrpc patients treated with first-line docetaxel between 2005 and 2007 at the Princess Margaret Hospital.

In the first-line setting, 88 patients with hrpc received docetaxel. The main reasons for initiating docetaxel were rising prostate-specific antigen (psa, 98%) and progressive symptoms (77%). The psa response rate was 67%; median time to response was 1.5 months, and duration of response was 6.8 months. Median survival was 15.9 months (95% confidence interval: 12.4 to 20.5 months). Patients received a median of 7 cycles of treatment, and the main toxicities were fatigue (35%) and neuropathy (24%). Post docetaxel, 36 patients received second-line treatment with a 22% response rate.

In routine clinical practice, hrpc patients received docetaxel mainly because of symptomatic disease progression. Overall response rates and toxicities were comparable to those in the tax 327 trial. However, our patients received a median of only 7 cycles of treatment versus the 9.5 administered on trial, and survival was slightly shorter in our single-institution study. A larger prospective multicentre analysis, including performance status and quality-of-life parameters, may be warranted to determine if docetaxel performs as well in routine clinical practice as it does in the clinical trial setting.

Written by:

Chin SN, Wang L, Moore M, Sridhar SS Are you the author?

Reference: Curr Oncol. 2010 Apr;17(2):24-9.

PubMed Abstract

PMID: 20404974 Forum: Castrate Resistant Prostate Cancer Title: Docetaxel: clinic vs clinical trial response rates

This extract can be found on http://PubMed.com, and is in the public domain.

On PubMed.com there will be a link to the full paper (often $30, sometimes free).

Any highlighting (except the title) is not by the author, but by Jim Marshall.

Jim is not a doctor.

This page was found on the Advanced Prostate Cancer Community for Australian men at http://advancedprost...lia.ipbhost.com.

The link is hard to remember.

An easier way to find it is to go to JimJimJimJim.com and click on Prostate.

That's the word Jim four times, no spaces, followed by .com.

If you need other help - to perhaps find someone to talk to or a local support group:

Click on the Contact Jim button at http://JimJimJimJim.com.

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