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Tablet bisphosphonates like Actonel not effective against metastases like infusion Zometa is

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Jim Marshall (not a doctor) said ...

Bisphosphonates protect the strength of bones.

Many elderly men and women take them in tablet form for osteoporosis.

One common tablet is Actonel (risedronate).

Other bisphosphonates are Zometa (Zoledronic acid, Zoledronate), Pamidronate, Fosamax (Alendronate), Bonefos (Clodronate), Clasteon (Clodronate), Loron (Clodronate).

Some strong bisphosphonates are given by infusion. They drip from a plastic bag through a tube directly into your blood. This is done every few weeks.

Zometa is the most common strong bisphosphonate that is given by infusion.

Zometa protects the strength your bones.

Zometa also protects your bones from advancing metastases, and can increase your survival time.

Zometa has one very worrying side effect for some people, especially if they have to have a tooth extraction. See the topic Osteonecrosis of the jaw (ONJ) risk factors identified for Zometa use on our website.

So, people were hoping a gentler tablet bisphosphonate, while preserving bone strength, would also protect bones from advancing metastases.

Sadly, in a test of a commonly prescribed tablet, Actonel (risedronate) given at the same time as Docetaxel/Taxotere chemotherapy showed no benefit against bone metastases or for survival.

If you wish to see the original article in OncologyStat, you will need a (free) account with Elsevier.


... end Jim

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