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Metastatic CRPC Phase III clinical trials - updated 12 Feb 2012


JimJimJimJim

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Metastatic CRPC Phase III clinical trials

Immunotherapy

Provenge (Sipuleucel-T)

Provenge vs. placebo

Chemotherapy naïve

Positive OS

Search http://ClinicalTrials.gov for: 00065442

PROSTVAC

PROSTVAC +/- GM-CSF vs.placebo

Chemotherapy naïve

Planned

Search http://ClinicalTrials.gov for: 01322490

Ipilimumab

Ipilimumab vs. placebo

Chemotherapy naïve

Open to accrual

Search http://ClinicalTrials.gov for: 01057810

Ipilimumab vs. placebo with radiotherapy

Post-docetaxel

Open to accrual

Search http://ClinicalTrials.gov for: 00861614

Hormonal agents

Abiraterone

Abiraterone/prednisone vs. placebo/prednisone

Chemotherapy naïve

Closed to accrual; results pending

Search http://ClinicalTrials.gov for: 00887198

Abiraterone/prednisone vs.placebo/prednisone

Post-docetaxel Positive OS benefit with abiraterone

Search http://ClinicalTrials.gov for: 00638690

TAK-700

TAK-700/prednisone vs. placebo/prednisone

Chemotherapy naïve

Open to accrual

Search http://ClinicalTrials.gov for: 01193244

TAK-700/prednisone vs.placebo/prednisone

Post-docetaxel

Open to accrual

Search http://ClinicalTrials.gov for: 01193257

MDV3100

MDV3100 vs. placebo

Chemotherapy naïve

Open to accrual

Search http://ClinicalTrials.gov for: 01212991

Bone-Targeted Therapy

Radium-223

Radium-223 vs. placebo

Unfit for docetaxel and post-docetaxel

Positive OS benefit with radium-223

Search http://ClinicalTrials.gov for: 00699751

Denosumab

Denosumab vs. zoledronic acid

mCRPC

Increased time-to-first SRE with denosumab

Search http://ClinicalTrials.gov for: 00321620

Chemotherapy

Docetaxel

Docetaxel/prednisone vs.mitoxantrone/prednisone

First-line chemotherapy

Positive OS benefit with docetaxel

Search http://ClinicalTrials.gov for: n/a

Docetaxel/estramustine vs.mitoxantrone/prednisone

First-line chemotherapy

Positive OS benefit with docetaxel

Search http://ClinicalTrials.gov for: 00004001

Cabazitaxel

Cabazitaxel/prednisone vs.mitoxantrone/prednisone

Post-docetaxel

Positive OS benefit with cabazitaxel

Search http://ClinicalTrials.gov for: 00417079

Cabazitaxel 20mg/m2 vs. Cabazitaxel 25mg/m2, both with prednisone

Post-docetaxel

Open to accrual

Search http://ClinicalTrials.gov for: 01308580

Cabazitaxel 20mg/m2 vs. Cabazitaxel 25mg/m2 vs. Docetaxel, all with prednisone

First-line chemotherapy

Open to accrual

Search http://ClinicalTrials.gov for: 01308567

From:

Approved Agents and Related Trials, Gary R. MacVicar, MD, Northwestern University, Chicago, IL

[Mitoxantrone is sometimes spelt mitozantrone]

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JimJimJimJim

Tony

Thanks for your question.

As a result:

  • I have edited the topic to make it clearer and to have clickable links to ClinicalTrials.gov; and
  • I am making a short video explaining how to do simple searches on ClinicalTrials.gov.

Jim

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