JimJimJimJim Posted February 12, 2012 Share Posted February 12, 2012 Metastatic CRPC Phase III clinical trials Immunotherapy Provenge (Sipuleucel-T) Provenge vs. placebo Chemotherapy naïve Positive OS Search http://ClinicalTrials.gov for: 00065442 PROSTVAC PROSTVAC +/- GM-CSF vs.placebo Chemotherapy naïve Planned Search http://ClinicalTrials.gov for: 01322490 Ipilimumab Ipilimumab vs. placebo Chemotherapy naïve Open to accrual Search http://ClinicalTrials.gov for: 01057810 Ipilimumab vs. placebo with radiotherapy Post-docetaxel Open to accrual Search http://ClinicalTrials.gov for: 00861614 Hormonal agents Abiraterone Abiraterone/prednisone vs. placebo/prednisone Chemotherapy naïve Closed to accrual; results pending Search http://ClinicalTrials.gov for: 00887198 Abiraterone/prednisone vs.placebo/prednisone Post-docetaxel Positive OS benefit with abiraterone Search http://ClinicalTrials.gov for: 00638690 TAK-700 TAK-700/prednisone vs. placebo/prednisone Chemotherapy naïve Open to accrual Search http://ClinicalTrials.gov for: 01193244 TAK-700/prednisone vs.placebo/prednisone Post-docetaxel Open to accrual Search http://ClinicalTrials.gov for: 01193257 MDV3100 MDV3100 vs. placebo Chemotherapy naïve Open to accrual Search http://ClinicalTrials.gov for: 01212991 Bone-Targeted Therapy Radium-223 Radium-223 vs. placebo Unfit for docetaxel and post-docetaxel Positive OS benefit with radium-223 Search http://ClinicalTrials.gov for: 00699751 Denosumab Denosumab vs. zoledronic acid mCRPC Increased time-to-first SRE with denosumab Search http://ClinicalTrials.gov for: 00321620 Chemotherapy Docetaxel Docetaxel/prednisone vs.mitoxantrone/prednisone First-line chemotherapy Positive OS benefit with docetaxel Search http://ClinicalTrials.gov for: n/a Docetaxel/estramustine vs.mitoxantrone/prednisone First-line chemotherapy Positive OS benefit with docetaxel Search http://ClinicalTrials.gov for: 00004001 Cabazitaxel Cabazitaxel/prednisone vs.mitoxantrone/prednisone Post-docetaxel Positive OS benefit with cabazitaxel Search http://ClinicalTrials.gov for: 00417079 Cabazitaxel 20mg/m2 vs. Cabazitaxel 25mg/m2, both with prednisone Post-docetaxel Open to accrual Search http://ClinicalTrials.gov for: 01308580 Cabazitaxel 20mg/m2 vs. Cabazitaxel 25mg/m2 vs. Docetaxel, all with prednisone First-line chemotherapy Open to accrual Search http://ClinicalTrials.gov for: 01308567 From: Approved Agents and Related Trials, Gary R. MacVicar, MD, Northwestern University, Chicago, IL [Mitoxantrone is sometimes spelt mitozantrone] Link to comment Share on other sites More sharing options...
tonymax Posted February 13, 2012 Share Posted February 13, 2012 Jim, How do I find out more about these trials? Tony M Link to comment Share on other sites More sharing options...
JimJimJimJim Posted February 16, 2012 Author Share Posted February 16, 2012 Tony Thanks for your question. As a result: I have edited the topic to make it clearer and to have clickable links to ClinicalTrials.gov; and I am making a short video explaining how to do simple searches on ClinicalTrials.gov. Jim Link to comment Share on other sites More sharing options...
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