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One man with a nearly 4 year response to Nilutamide as secondary hormone therapy


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Am J Ther. 2005 Mar-Apr;12(2):172-4.

Prolonged response to nilutamide in a patient with stage D0.5 prostate cancer who previously failed androgen deprivation therapy.

Todd NF, Lieberman R, Gulley JL, Dahut W, Arlen PM.


Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.


There is currently no standard therapy for patients with prostate cancer who have progressive rise in PSA levels despite treatment with hormonal ablation and antiandrogen withdrawal (stage D0.5). One potential treatment option is the use of a different androgen receptor antagonist (ARA), such as nilutamide. We report a case of a 66-year-old gentleman with greater than a 46 month sustained response to nilutamide therapy after failing bicalutamide therapy and its subsequent withdrawal. The patient continues to have undetectable PSA levels and an excellent performance status. This case demonstrates the prolonged response to a second-line ARA in patients deemed to have androgen insensitive prostate cancer. Further investigation of the potential role of nilutamide therapy as second-line antiandrogen therapy is warranted as monotherapy and/or in combination with other promising novel approaches including PSA-based vaccines.

PMID: 15767834

This extract can be found on http://PubMed.com, and is in the public domain.

On PubMed.com there will be a link to the full paper (often $30, sometimes free).

Any highlighting (except the title) is not by the author, but by Jim Marshall.Jim is not a doctor.

Nilutamide is an antiandrogen that is used when primary hormone therapy fails, and your PSA starts rising again.

Using drugs when primary hormone therapy fails is called a 'secondary hormone therapy'.

For some men, there can be a good response.

For a few men, the response can be very good, as with the man reported above who had nearly 4 years progression free.

Details of Nilutamide response can be found in this topic on our Community:

Nilutamide response in 40%

and in this one:

Nilutamide after primary

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