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Vitamin D insufficiency prevalent in non-metastatic PCa

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Vitamin D insufficiency is common in patients with nonmetastatic prostate cancer - Abstract

Thursday, 10 March 2011

Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

Because an inverse relationship between serum 25-hydroxyvitamin D (25[OH]D) levels and the risk of prostate cancer has been suggested, it was hypothesized that vitamin D insufficiency would be common in patients with prostate cancer. To test the hypothesis, an exploratory study was conducted to examine serum 25(OH)D levels in a cohort of patients with nonmetastatic prostate cancer. The study aim was to assess the prevalence of vitamin D insufficiency in these patients. Vitamin D insufficiency was defined as serum 25(OH)D less than 75 nmol/L. Serum 25(OH)D levels measured prospectively at baseline and, then, yearly during a 5-year follow-up were analyzed. Various parameters were examined to assess their possible association with vitamin D insufficiency at baseline, using both a univariate analysis and a logistic regression model. Analyses including descriptive statistics for all variables were carried out with SAS version 9.1 (SAS Institute, Cary, NC). A total of 106 patients were available for analysis. The median age was 66.3 years. At baseline, mean and median vitamin D level was 72.4 and 70.0 nmol/L, respectively. Sixty-four patients (60.4%) met the definition of vitamin D insufficiency with serum 25(OH)D less than 75 nmol/L. Forty (37.7%), 20 (18.9%), and 2 patients (1.9%) had serum 25(OH)D less than 62.5, less than 50, and less than 25 nmol/L, respectively. On a logistic regression model, season was the only significant variable associated with vitamin D insufficiency. Of a total 477 serum 25(OH)D measurements from the baseline and yearly follow-ups, 187 (39.2%) met the definition of vitamin D insufficiency. In conclusion, vitamin D insufficiency was prevalent among patients with nonmetastatic prostate cancer.

Written by:

Choo CS, Mamedov A, Chung M, Choo R, Kiss A, Danjoux C.

Reference: Nutr Res. 2011 Jan;31(1):21-6.

doi: 10.1016/j.nutres.2010.12.007

PubMed Abstract

PMID: 21310302 Forum: Other prostate cancer topics including radiation Title: Vitamin D insufficiency prevalent in non-metastatic PCa

This extract can be found on http://PubMed.com, and is in the public domain.

On PubMed.com there will be a link to the full paper (often $30, sometimes free).

Any highlighting (except the title) is not by the author, but by Jim Marshall.

Jim is not a doctor.

This page was found on the Advanced Prostate Cancer Community for Australian men at http://advancedprost...lia.ipbhost.com.

The link is hard to remember.

An easier way to find it is to go to JimJimJimJim.com and click on Prostate.

That's the word Jim four times, no spaces, followed by .com.

If you need other help - to perhaps find someone to talk to or a local support group:

Click on the Contact Jim button at http://JimJimJimJim.com.

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