Docetaxel and epirubicin in CRPC

[JimmyToowong]

Docetaxel and epirubicin compared with docetaxel and prednisone in advanced castrate-resistant prostate cancer: A randomised phase II study - Abstract

Thursday, 03 March 2011

Medical Oncology Unit, University of Siena, Viale Bracci 11, 53100, Siena, Italy.

This randomised phase II study compared the activity and safety of the combination docetaxel (D)/epirubicin (EPI) [jm] with the conventional treatment D/prednisone (P) in advanced castrate-resistant prostate cancer (CRPC) patients.

Patients were randomly assigned to D 30?mg?m(-2) as intravenous infusion (i.v.) and EPI 30?mg?m(-2) i.v. every week (D/EPI arm), or D 70?mg?m(-2) i.v. every 3 weeks and oral P 5?mg twice daily (D/P arm). Chemotherapy was administered until disease progression or unacceptable toxicity.

A total of 72 patients were enrolled in the study and randomly assigned to treatment: 37 to D/EPI and 35 to D/P. The median progression-free survival (PFS) was 11.1 months (95% CI 9.2-12.6 months) in the D/EPI arm and 7.7 months (95% CI 5.7-9.4 months) in the D/P arm (P=0.0002). The median survival was 27.3 months (95% CI 22.1-30.8 months) in the D/EPI arm and 19.8 months (95% CI 14.4-24.8 months) in the D/P arm (P=0.003). Both regimens were generally well tolerated.

The treatment of advanced CRPC with weekly D combined with weekly EPI was feasible and tolerable, and led to superior PFS than the treatment with 3-weekly D and oral P.

Written by:

Petrioli R, Pascucci A, Conca R, Chiriacò G, Francini E, Bargagli G, Fiaschi AI, Manganelli A, De Rubertis G, Barbanti G, Ponchietti R, Francini G.

Reference: Br J Cancer. 2011 Feb 15;104(4):613-9.

doi: 10.1038/bjc.2011.5

PubMed Abstract

PMID: 21285986 Forum: New agents Title: Docetaxel and epirubicin in CRPC

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