JimmyToowong Posted July 31, 2011 Share Posted July 31, 2011 Can J Urol. 2007 Aug;14(4):3621-7. What is the optimal duration of androgen deprivation therapy in prostate cancer patients presenting with prostate-specific antigen levels > 20 ng/ml? Berthelet E, Pickles T, Truong PT, Liu M, Pai HH, Kwan WB, Lim JT; Members of the Prostrate Cancer Outcomes Initiative. Vancouver Island Centre, BC Cancer Agency, University of British Columbia, British Columbia, Canada. Abstract PURPOSE: To evaluate the optimal duration of androgen deprivation therapy (ADT) in patients with prostate cancer treated with external beam radiotherapy (EBRT), who present with PSA levels > 20 ng/mL. METHODS AND MATERIALS: A total of 307 patients presenting with a PSA > 20 ng/ml were treated with EBRT and ADT. The cohort was divided into four groups according to the duration of ADT: Group 1 received < 6 months (n = 71), group 2 received 6-12 months (n = 80), group 3 received 12-24 months (n = 72), and group 4 received > 24 months (n = 84) of ADT. The endpoints analyzed were biochemical control (bNED), overall survival (OS) and cause-specific survival (CSS). Statistical analysis was conducted using Kaplan-Meier estimates and Cox regression models. RESULTS: Compared to patients who received < 6 months of ADT, patients treated with 12-24 months or > 24 months of ADT experienced significantly improved bNED (p = 0.01 and p < 0.0001, respectively). Cause-specific survival with ADT durations 12-24 and > 24 months were significantly higher compared to < 6 months (p < 0.007 and 0.024, respectively). Overall survival with ADT durations > 24 months was also significantly higher compared to < 6 months (p = 0.0025). CONCLUSIONS: The present analysis supports the hypothesis that longer durations of ADT improves bNED, CSS and OS in patients presenting with a PSA > 20 ng/ml. PMID: 17784982 Forum: Primary hormone therapy Title: If initial PSA > 20 ng/ml, longer ADT improves progression free and overall survival This extract can be found on http://PubMed.com, and is in the public domain. On PubMed.com there will be a link to the full paper (often $30, sometimes free). Any highlighting (except the title) is not by the author, but by Jim Marshall. Jim is not a doctor. This page was found on the Advanced Prostate Cancer Community for Australian men at http://advancedprost...lia.ipbhost.com. The link is hard to remember. An easier way to find it is to go to JimJimJimJim.com and click on Prostate. That's the word Jim four times, no spaces, followed by .com. If you need other help - to perhaps find someone to talk to or a local support group: Click on the Contact Jim button at http://JimJimJimJim.com. Link to comment Share on other sites More sharing options...
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