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In recurrence after prostatectomy PSA doubling predicts


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Future Oncol. 2007 Aug;3(4):393-5.

Prostate-specific antigen kinetics after failure of primary prostate cancer therapy: a valuable prognostic factor.

Pickles T.

BC Cancer Agency, Radiation Oncology Program, Clinical Professor, University of British Columbia, 600 West 10th Avenue, Vancouver, BC V5Z 4E6, Canada.

Comment on:

J Clin Oncol. 2007 May 1;25(13):1765-71.


Evaluation of: Freedland SJ, Humphreys EB, Mangold LA et al.: Death in patients with recurrent prostate cancer after radical prostatectomy: prostate-specific antigen doubling time subgroups and their associated contributions to all-cause mortality. J. Clin. Oncol. 25(13), 1765-1771 (2007). In this article by Freedland and colleagues, prostate-specific antigen doubling time (PSAdt) is shown as a strong prognostic factor for subsequent death. Those with fast doubling times (< 3-6 months) have a relatively short disease course, with a median survival of 6.5 years, whereas those with slow doubling times (>/=15 months) have relatively indolent disease with prostate cancer-specific mortality rates of under 5% after 10 years. Prostate cancer is the most common cause of death for those with a PSAdt of less than 15 months. These patients may be selected for consideration of early secondary intervention and experimental management, although there is no clear evidence that earlier, as opposed to later, intervention leads to an overall survival gain, and quality of life may be adversely affected by intervention. The intelligent use of PSAdt allows the selection of those in whom early intervention may be avoided.

PMID: 17661713 Forum: Castrate Resistant Prostate Cancer Title: In recurrence after prostatectomy PSA doubling predicts survival or death

This extract can be found on http://PubMed.com, and is in the public domain.

On PubMed.com there will be a link to the full paper (often $30, sometimes free).

Any highlighting (except the title) is not by the author, but by Jim Marshall.

Jim is not a doctor.

This page was found on the Advanced Prostate Cancer Community for Australian men at http://advancedprost...lia.ipbhost.com.

The link is hard to remember.

An easier way to find it is to go to JimJimJimJim.com and click on Prostate.

That's the word Jim four times, no spaces, followed by .com.

If you need other help - to perhaps find someone to talk to or a local support group:

Click on the Contact Jim button at http://JimJimJimJim.com.

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