Paul Edwards Posted January 20, 2016 Share Posted January 20, 2016 Trial stopped - see below. Men who are on androgen deprivation therapy and who have metastases may be interested in the following Phase 3 clinical trial:A Study of Galeterone Compared to Enzalutamide In Men Expressing Androgen Receptor Splice Variant-7 mRNA (AR-V7) Metastatic CRPC (ARMOR3-SV) Details of this trial are available at XXXXXXXXX To be eligible, you must not have been treated with abiraterone, enzalutamide or chemotherapy. You must have detectable AR-V7 (your circulating tumour cells will be tested as part of the eligibility process). If accepted for the trial, you will receive active drugs, not placebos. You will receive either Galeterone or Enzalutamide. Galeterone (TOK-001) is a new steroidal antiandrogen under development by Tokai Pharmaceuticals for the treatment of prostate cancer. It possesses a unique dual mechanism of action, acting as both an androgen receptor antagonist and an inhibitor of CYP17A1, an enezyme required for the biosynthesis of the androgens. Galeterone may benefit men who carry the AR-V7 subtype of Castrate Resistant Prostate Cancer and who therefore do not respond well to treatment with either abiraterone or enzalutamide. The trial is currently recruiting participants at the following Australian trial sites listed below: Peter MacCallum Cancer Centre, 2 St. Andrews Place, East Melbourne, VIC, 3002 North Coast Cancer Institute,Wrights Road, Port Macquarie, NSW, 2444 Ashford Cancer Centre/Adelaide Cancer Centre Research, 520 South Road, Kurralta Park, NSW, 5037 Box Hill Hospital, Monash University and Eastern Health Clinical School, Level 2, 5 Arnold Street, Box Hill, VIC, 3128 Macquarie University, Urology Macquarie University Clinic Suite 304 Level 3, 2 Technology Place, Sydney, NSW, 2109 Cabrini Hospital,Suite 19, 183 Wattletree Rd, Malvern, VIC, 3144, AU ICON Cancer Care, 39 White Street, Southport, QLD 4215 Monash Medical Centre, East Bentleigh, 865 Centre Road, East Bentleigh, VIC, 3165 Peninsula Specialist Centre, 101 George Street, Kippa-Ring, QLD 4021 Princess Alexandra Hospital, Ipswich Road, Woollongabba, QLD, 4102 St. George Private Hospital, Oncology Day Care Centre, 1 South Street, Kogarah, NSW, 2217 Link to comment Share on other sites More sharing options...
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