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Metabolic syndrome, earlier progression, lower survival

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Presence of the metabolic syndrome is associated with shorter time to castration-resistant prostate cancer

Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis.

Metabolic syndrome (MS) is a set of risk factors that includes obesity and insulin resistance and has been implicated in the development of prostate cancer. Its impact on androgen deprivation therapy (ADT) efficacy has not been studied.

Retrospective study of prostate cancer patients seen from 1998 to 2005 in a medical oncology clinic. MS, as defined by modified Adult Treatment Panel III criteria, was assessed at the time of initiation of ADT. The study end points were time to prostate-specific antigen (PSA) progression and overall survival (OS) from time of starting ADT.

Eighty-two patients treated with ADT and data to assess for presence of MS were identified. Median age in men with and without MS was 70 years and 49% of the patients evaluated met criteria for MS. Median time to PSA progression for patients with MS was 16 versus 36 months without MS (P = 0.003). The median OS for patients with MS was 36.5 months after commencing ADT compared with 46.7 months for those patients without MS (P = 0.061).

This preliminary data suggest that MS is a risk factor for earlier development of castration-resistant prostate cancer and support the need for a prospective evaluation of this finding.

Written by:

Flanagan J, Gray PK, Hahn N, Hayes J, Myers LJ, Carney-Doebbeling C, Sweeney CJ. [1]

Reference: Ann Oncol. 2010 Sep 29. Epub ahead of print.

doi: 10.1093/annonc/mdq443

PMID: 20880998 Forum: Other prostate cancer topics including radiation Title: Metabolic syndrome, earlier progression, lower survival

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This extract can be found on http://PubMed.com, and is in the public domain.

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