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BMI no longer an issue in RT with modern aiming

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Cancer. 2010 Aug 5. Epub ahead of print.

Impact of body mass index on outcomes after conformal radiotherapy in patients with prostate cancer

Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.

Several retrospective analyses have suggested that obese men with prostate cancer treated with external beam radiotherapy (EBRT) have outcomes inferior to those of normal-weight men. However, a recently presented analysis for the first time challenged this association between body mass index (BMI) and treatment failure. It is therefore important to provide further data on this issue.

This was a retrospective analysis of 564 men treated with risk-adapted conformal EBRT at a single institution. Low-risk patients received EBRT alone, and the other patients received EBRT plus endocrine treatment. In addition, high-risk patients were treated to higher EBRT doses (74 Gy). A rectal balloon catheter for internal immobilization, which can be identified on portal images, was used in 261 patients (46%). Thus, localization did not rely on bony landmarks alone in these cases.

The median BMI was 26, and 15% of patients had BMI ?30. Neither univariate nor multivariate analyses detected any significant impact of BMI on biochemical relapse, prostate cancer-specific survival, or overall survival. The 5-year biochemical relapse rate was 21% and prostate cancerspecific survival 96%.

The present analysis of a large cohort of consecutively treated patients suggests that efforts to reduce prostate movement and geographic miss might result in comparable outcomes in obese and normal-weight patients.

Written by:

Geinitz H, Thamm R, Mueller T, Jess K, Zimmermann FB, Molls M, Nieder C. [1]

Reference: Int J Radiat Oncol Biol Phys. 2010 Sep 21. Epub ahead of print.

doi: 10.1016/j.ijrobp.2010.05.059

PMID: 20864272 Forum: Other prostate cancer topics including radiation Title: BMI no longer an issue in RT with modern aiming

This extract can be found on http://PubMed.com, and is in the public domain.

On PubMed.com there will be a link to the full paper (often $30, sometimes free).

Any highlighting (except the title) is not by the author, but by Jim Marshall.

Jim is not a doctor.

This page was found on the Advanced Prostate Cancer Community for Australian men at http://advancedprost...lia.ipbhost.com.

The link is hard to remember.

An easier way to find it is to go to JimJimJimJim.com and click on Prostate.

That's the word Jim four times, no spaces, followed by .com.

If you need other help - to perhaps find someone to talk to or a local support group:

Click on the Contact Jim button at http://JimJimJimJim.com.

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