ADT adds 2.2 kg first year, then stable weight

[JimmyToowong]

A natural history of weight change in men with prostate cancer on androgen-deprivation therapy (ADT): Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database

Urologic Surgery, Department of Surgery, and the Duke Prostate Center, Duke University School of Medicine, Durham, NC.

Urology Section, Veterans Affairs Medical Center, Durham, NC; Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA; Department of Urology, Stanford University Medical Center and Urology Section, Department of Surgery, Veterans Affairs Medical Center, Palo Alto, CA; Urology Section, Department of Surgery, Veterans Affairs Medical Center, Greater Los Angeles, Los Angeles, CA; Urology Section, Division of Surgery, Veterans Affairs Medical Centers and Division of Urologic Surgery, Department of Surgery, Medical College of Georgia, Augusta, GA; Division of Urology, Department of Surgery, University of California at San Diego Medical Center, San Diego, CA; Division of Urology, Department of Surgery, Oregon Health & Science University, Portland, OR, Division of Urologic Surgery, Department of Surgery and Department of Pathology, Duke University School of Medicine, Durham, NC; and Urology Section, Veterans Affairs Medical Center, Durham, NC, USA.

Study Type - Harm (cohort) ?Level of Evidence?2b.

To better understand the natural history of weight change with androgen-deprivation therapy (ADT), we investigated the effect of ADT on body weight among men from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. Men undergoing ADT lose lean muscle but gain fat mass, contributing to an overall gain in weight.

We identified 132 men in SEARCH who received ADT after radical prostatectomy. 'Weight change' was defined as the difference in weight before starting ADT (6 months before ADT) and the on-ADT weight (between 6 and 18 months after starting ADT). In a subanalysis, baseline characteristics of weight-gainers and -losers were analysed using univariate and multivariate analysis to test association with weight change.

In all, 92 men (70%) gained weight, and 40 (30%) either lost or maintained a stable weight. On average, weight on ADT was 2.2?kg higher than the weight before ADT, with the mean change for weight-gainers and -losers being +4.2?kg and -2.4?kg, respectively. This compared with no significant weight change in the year before starting ADT (paired t-test, change -0.7?kg, P= 0.19) or in the second year on ADT (paired t-test, change -0.5?kg, P= 0.46) for 84 men in whom these additional weight values were recorded. There was no significant association between any of the features examined and weight change on univariate and multivariate analysis.

In this longitudinal study, ADT was accompanied by significant weight gain (+2.2?kg). This change occurred primarily in the first year of therapy, with men neither losing nor gaining additional weight thereafter.

Written by:

Kim HS, Moreira DM, Smith MR, Presti JC Jr, Aronson WJ, Terris MK, Kane CJ, Amling CL, Freedland SJ. [1]

Reference: BJU Int. 2010 Sep 22. Epub ahead of print.

doi: 10.1111/j.1464-410X.2010.09679.x

PMID: 20860651 Forum: Primary hormone therapy Title: ADT adds 2.2 kg first year, then stable weight

This extract can be found on http://PubMed.com, and is in the public domain.

On PubMed.com there will be a link to the full paper (often $30, sometimes free).

Any highlighting (except the title) is not by the author, but by Jim Marshall.

Jim is not a doctor.

This page was found on the Advanced Prostate Cancer Community for Australian men at http://advancedprost...lia.ipbhost.com.

The link is hard to remember.

An easier way to find it is to go to JimJimJimJim.com and click on Prostate.

That's the word Jim four times, no spaces, followed by .com.

If you need other help - to perhaps find someone to talk to or a local support group:

Click on the Contact Jim button at http://JimJimJimJim.com.