bicalutamide then flutamide and vice-versa

[JimmyToowong]

Alternative antiandrogen therapy in patients with castration-resistant prostate cancer: A single-center experience - Abstract

Wednesday, 22 September 2010

Department of Urology, The University of Kyorin, Mitaka, Tokyo, Japan.

Outcomes of alternative (second-line) antiandrogen therapy in 112 patients with relapsing prostate cancer after first-line hormonal therapy were analyzed. A good response (prostate-specific antigen [PSA] decrease >/=50%) and a partial response (PSA decrease of 0-50%) by switching from bicalutamide (BCL) to flutamide (FLT) and from FLT to BCL were achieved in 35.4% (28/79) and 30.4% (24/79), and in 45.0% (9/20) and 20.0% (4/20) of cases, respectively. A good response and a partial response with the change from chlormadinone acetate (CMA) to a non-steroidal antiandrogen (FLT or BCL) and from a non-steroidal antiandrogen to CMA were obtained in 25.0% (2/8) and 37.5% (3/8), and in 20.0% (1/5) and 0% (0/5) of cases, respectively. In multivariate analyses, a second-line good response was significantly predictive of cause-specific survival from first therapy relapse to cancer death in all patients. Patients (52/112, 46.4%) with >/=30% decrease in PSA levels were associated with significantly better cause-specific survival as measured from the start of first-line treatment and first-line relapse.

Written by:

Okegawa T, Nutahara K, Higashihara E.

Reference: Int J Urol. 2010 Aug 27. Epub ahead of print.

PMID: 20807265 Forum: Secondary hormone therapy Title: bicalutamide then flutamide and vice-versa

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