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Mice trials suggest HIV Drug could block prostate cancer metastases

Charles (Chuck) Maack

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Still in the early stages of study, but appears promising in the future for reining in/slowing prostate cancer development.


HIV drug blocks bone metastases in prostate cancer http://tinyurl.com/ppju6bz



Although prostate cancer can be successfully treated in many men, when the disease metastasises to the bone, it is eventually lethal. The receptor CCR5, targeted by HIV drugs, is also key in driving prostate cancer metastases, suggesting that blocking this molecule could slow prostate cancer spread.”


“…maraviroc dramatically reduced the overall metastatic load by 60 percent in the bone, brain and other organs”





Internationally known as Selzentry


This medication is an anti-retroviral agent, prescribed for HIV infection (CCR5-tropic HIV-1 detectable). It works by blocking the virus from entering cells

Contraindicated in patients with severe kidney problems, who are taking St. John's Wort, and hypersensitivity.

Read more: Maraviroc (Selzentry) Drug Information - Indications, Dosage, Side Effects and Precautions | Medindia http://www.medindia.net/doctors/drug_information/maraviroc.htm#ixzz3KlBY2OrC



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The "New" Prostate Cancer Infolink has a post about this research:




It concludes that:


"At this time, and based on the available data, The “New” Prostate Cancer InfoLink advises that patients with prostate cancer should not take or use maraviroc unless (i) it is being prescribed to treat HIV/AIDS in a man who also has prostate cancer or (ii) it is taken to treat prostate cancer in an IRB-approved clinical trial"

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