Effects of mega-3 polyunsaturated fatty acids on PSA

[JimmyToowong]

Effects of eicosapentaenoic acid on biochemical failure after radical prostatectomy for prostate cancer - Abstract Show Comments PDF Print E-mailMonday, 16 August 2010

Department of Urology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo. 181-8611 Japan.

Fax: +81 422477553, ehigashi@ks.kyorin-u.ac.jp.This email address is being protected from spam bots, you need Javascript enabled to view it

To study the effects of eicosapentaenoic acid (EPA) [jm] on prostate-specific antigen (PSA) failure in prostate cancer patients who underwent prostatectomy.

Sixty-two prostate cancer patients whose PSA levels were less than 0.2 ng/ml 3 months after surgery were randomized to either an EPA group (n=32) or a control group (n=30). EPA (2.4 g/day) was administered in the EPA group for 2 years. PSA was measured every two months.

The EPA concentration increased but the docosahexaenoic acid concentration decreased significantly (P<0.001) in erythrocytes. The PSA recurrence rates during a mean follow-up of 53.8 months were not different between the two groups (p=0.16).

A longer and/or larger intervention or docosahexaenoic acid supplementation might be necessary to identify significant preventive effects of mega-3 polyunsaturated fatty acids on PSA recurrence.

Written by:

Higashihara E, Itomura M, Terachi T, Matsuda T, Kawakita M, Kameyama S, Fuse H, Chiba Y, Hamazaki T, Okegawa T, Tokunaga M, Murota T, Kawa G, Furuya Y, Akashi T, Hamazaki K, Takada H.

Reference: In Vivo. 2010 Jul-Aug;24(4):561-5.

PubMed Abstract

PMID: 20668324 Forum: Every little bit helps Title: Effects of mega-3 polyunsaturated fatty acids on PSA recurrence

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