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  1. I was diagnosed with an aggressive prostate cancer (Gleeson 10) in June 2017. Following the diagnosis I was immediately put on ADT using Zolodex and have been on it continuously since. I have also undergone 8 weeks of radiation therapy. To date treatment has been successful and I have had a PSA level of 0.02 for about the last 18 months. My problem is that I have uncontrollable mood swings in which I become quite angry and short tempered. I also have thoughts that have no basis in reality during these swings which is putting considerable pressure on my family. My trouble is that I can feel the mood change coming on but do not seem to be able to control it. I have considered seeking professional psychological/psychiatric help but before I do was wondering if anyone on this forum has experienced this whilst on ADT and if so how do you overcome or control them. Any advice would be welcome.
  2. This video today is about weight training for men on hormone therapy for prostate cancer. Hormone therapy is also called 'Androgen Deprivation Therapy' (ADT) because it robs a man of androgens. The main androgen is testosterone. Androgens fuel prostate cancer. And a reminder that we have a few videos of our own on the JimJimJimJim channel: https://www.youtube.com/jimjimjimjim/videos The Prostate Cancer Research Institute (PCRI) is an important source of information for about prostate cancer for patients, families, and the medical community. As part of their mission to empower men and their caregivers they make YouTube videos.
  3. alanbarlee

    Hot flushes from ADT

    Margaret asked about hot flushes at our September 2019 call-in conference. Here's some up-to-date information from one our leading urologists. Hot flushes (extracts from ACCP Consensus Conference 2019 - UroToday) The important topic of hot flushes caused by androgen deprivation therapy (ADT) was discussed by Dr. Frydenberg (Melbourne urologist). Hot flushes are defined as a subjective feeling of warmth in the upper torso, followed by excessive perspiration. Approximately 80-90% of men on ADT endure hot flushes, with 27% reporting them as the most troublesome side effect. Hot flushes have been associated with patient embarrassment, helplessness, and distress during treatment. They can last for the entire duration of treatment and significantly affect quality of life and sleep. The reduction of plasma sex hormones levels from previous normal levels alters the function of brain neurotransmitters such as noradrenaline, serotonin, GABA, dopamine, and beta-endorphins. The thermoregulatory centre in the hypothalamus is anatomically close to the LHRH secreting neurons, and by proximity, the thermoregulatory centre can be reset. There is a positive correlation between hot flushes and LH surges. Hot flushes have been reported to worsen with longer ADT treatment durations and are also worse in younger men with lower BMI.3 Some complementary treatments that can be used include: Exercise – especially high-intensity aerobics and resistance training Cognitive-behavioural therapy Diet – no benefit has been shown in randomized controlled trials for phytoestrogens Acupuncture – reports of 70-80% reduction in flushes with either dry needling or electro stimulated needling. Moreover, patients maintained less than 50% reduction in their hot flushes 9 months after cessation of treatment in 46% of patients. Hot flushes are a common and troublesome side effect of ADT. It is imperative that patients avoid known triggers of hot flushes and promote conservative therapies. An intermittent androgen blockade is a good option where appropriate and safe. It is reasonable to consider progesterone and SSRI/SNRI (anti-depressants) as first-line medical therapy. Lastly, complementary therapies are always recommended (acupuncture and exercise).
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