Paul Edwards Posted June 12, 2014 Share Posted June 12, 2014 Patients with castration-resistant prostate cancer and bone metastases may experience debilitating pain that impacts daily functioning and diminishes the quality of life. Previous results from a phase III trial demonstrated superiority of Denosumab (brand name Xgeva) to Zoledronic Acid (brand name Zometa) in delaying or preventingskeletal-related events (pathological fracture, radiation or surgery to the bone, spinal cord compression) in castration-resistant prostate cancer patients with bone metastases. Participants in this trial regularly completed Pain Inventory and Quality of Life questionaiires. Researchers did an ad hoc analysis of this trial which focused on the subgroup of men with no or mild pain at the start of the trial. This analysis showed that that Denosumab therapy significantly delayed the time to worsening of pain interference and maintained a higher overall cancer specific quality of life compared to Zoledronic Acid in castration-resistant prostate cancer patients with bone metastases. Should you be having Denosumab instead of Zoledronic Acid? I agree with Joel Nowak that you should "Speak with your doctor about this question.” Previous posts about Denosumab v Zoledronic Acid are at http://forums.jimjimjimjim.com/index.php?/topic/534-denosumab-or-zometa-for-protection-of-bones-in-prostate-cancer/ http://forums.jimjimjimjim.com/index.php?/topic/535-denosumab-or-zometa-for-protection-of-bones-in-breast-cancer/?hl=zometa Link to comment Share on other sites More sharing options...
Paul Edwards Posted June 20, 2014 Author Share Posted June 20, 2014 Joel Nowak has just done another post on his blog: "What you Need to Know About Denosumab (Xgeva)" . In it he warns that Xgeva "is a powerful drug with the potential of serious side effects" and discusses those side effects. Link to comment Share on other sites More sharing options...
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