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Enzalutamide trial in Australia for men with metastatic prostate cancer

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JimJimJimJim

Jim Marshall (not a doctor) said ...


The ENZAMET trial is one of the two clinical trials of the drug Enzalutamide that have now begun in Australia.


 


The ENZAMET trial is for men who have metastatic prostate cancer. 


 


Men in the trial will have standard hormone therapy - an LHRH agonist such as Zoladex plus an non-steroidal anti-androgen. 


 


Half the men will use one of the current non-steroidal anti-androgens (bicalutamide, nilutamide or flutamide).


The other half will use the new non-steroidal anti-androgen Enzalutamide.


 


You cannot enter this trial if you have had your prostate cancer treated by: 


hormone treatment longer than 2 years.


 


There are more detailed rules of how you may or may not qualify available from the trial site:


https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=365575


 


The hospitals offering this trial are:


 


Northern Cancer Institute - Frenchs Forest - Frenchs Forest


Royal Prince Alfred Hospital - Camperdown


Prince of Wales Hospital - Randwick


Concord Private Hospital - Concord


St Vincent's Hospital (Darlinghurst) - Darlinghurst


Wollongong Hospital - Wollongong


St George Hospital - Kogarah


Sydney Adventist Hospital - Wahroonga


Nepean Hospital - Kingswood


Port Macquarie Base Hospital - Port Macquarie


Peter MacCallum Cancer Institute - East Melbourne


St Vincent's Hospital (Melbourne) Ltd - Fitzroy


Epworth Eastern Hospital - Box Hill


Austin Health - Austin Hospital - Heidelberg


Peninsula Oncology Centre - Frankston


Royal Brisbane & Womens Hospital - Herston


Princess Alexandra Hospital - Woolloongabba


Nambour General Hospital - Nambour


Gold Coast Hospital - Southport


The Royal Adelaide Hospital - Adelaide


Flinders Medical Centre - Bedford Park


Royal Perth Hospital - Perth


Royal Hobart Hospital - Hobart


Royal Darwin Hospital - Tiwi


 


Non-steroidal anti-androgens include:


Cosudex/Casodex (bicalutamide), Anandron/ Nilandron (Nilutamide), Eulexin (Flutamide), Enzalutamide.


 


Androcur (Cyproterone), is a steroidal anti-androgen)


 


PCFA also has an excellent description of this trial at:


http://www.prostate.org.au/articleLive/pages/Australian-Organisation-Launches-Large-International-Clinical-Trials-in-Prostate-Cancer.html


 


 


... end Jim


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