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JimJimJimJim

Partial, unverified prostate cancer drug glossary for checking spelling ONLY

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JimJimJimJim

LHRH agonists, LHRHa

Zoladex (Goserelin), Lupron (leuprorelin), Eligard (leuprolide), Lucrin (leuprorelin acetate),  Suprefact (buserelin), Suprecor (buserelin), Synarel (nafarelin), histrelin (Supprelin), Suprelorin (deslorelin), Ovuplant (deslorelin), Triptorelin

GnRH antagonists, GnRHa

Abarelix, Firmagon (degarelix)

Anti-androgen, AA

Cosudex/Casodex (bicalutamide), Anandron/ Nilandron (Nilutamide), Eulexin (Flutamide), all nonsteroidal, and Androcur (Cyproterone, a steroid), Nizoral (Ketoconazole), and sometimes Zytiga (abiraterone acetate) and Xtandi (enzalutamide) are regarded as anti-androgens.

(In the USA Zytiga (abiraterone) is covered by insurance after chemotherapy with Taxotere (docetaxel). In late 2012, the USA FDA approved its use pre-chemotherapy. In Australia, as of 17 December 2012, Zytiga (abiraterone) may be prescribed, but is not covered by PBS. Xtandi (enzalutamide) was given USA FDA approval in August 2012 for use after chemotherapy. It is not available in Australia.)

5-alpha reductase inhibitors, 5ARI

Avodart (dutasteride) which inhibits types I & II, Proscar (Finasteride), Propecia (Finasteride) which inhibits only type II

Estrogen

DES Diethyl diphosphate (stilbestrol, Stilphostrol, Stilbestrol), Estradiol (also spelled oestradiol).

Androgen-receptor signalling inhibitor

Xtandi (Enzalutamide) (MDV3100)

Cancer vaccines

 Provenge (sipuleucel-T) (IV+), ProstVac (injectable)

Microtubule inhibitor

Jevtana (Cabazitaxel) (IV) (FDA: Post docetaxel)

Monoclonal antibody - effective prostate cancer

Xgeva (denosumab) A fully human monoclonal antibody for prevention of skeletal-related events for patients with bone metastases from solid tumors. Yervoy (ipilimumab) is an antibody that a brake that prevents immune cells from attacking the body’s own tissues and cells in melanoma tumors.

Other monoclonal antibodies
A , Abagovomab , Adecatumumab , Alemtuzumab , Anatumomab mafenatox , B , Bavituximab , Bectumomab , Bevacizumab , Bivatuzumab mertansine , Blinatumomab , C , Cancer immunotherapy , Cantuzumab mertansine , Catumaxomab , Cetuximab , D , Dacetuzumab , Detumomab , Duligotumab , E , Edrecolomab , Elotuzumab , Epratuzumab , Ertumaxomab , Etaracizumab , F , Figitumumab , Futuximab , G , Gavilimomab , G cont. , Gemtuzumab ozogamicin , Glembatumumab vedotin , I , Ibritumomab tiuxetan , Imgatuzumab , Indium (111In) altumomab pentetate , Indium (111In) igovomab , Inotuzumab ozogamicin , Ipilimumab , Iratumumab , L , Labetuzumab , Lambrolizumab , Lexatumumab , Lintuzumab , Lirilumab , Lorvotuzumab mertansine , Lucatumumab , M , Mapatumumab , Margetuximab , Matuzumab , Minretumomab , Mitumomab , Monoclonal antibody therapy , Template:Monoclonals for tumors , N , Nacolomab tafenatox , N cont. , Naptumomab estafenatox , Nimotuzumab , O , Ofatumumab , Oregovomab , P , Panitumumab , Parsatuzumab , Patritumab , Pemtumomab , Pritumumab , R , Reditux , Rituximab , S , Sibrotuzumab , T , Taplitumomab paptox , Technetium (99mTc) pintumomab , Tovetumab , Trastuzumab , Trastuzumab emtansine , Tucotuzumab celmoleukin , V , Vantictumab , Volociximab , Y , Yttrium (90Y) tacatuzumab tetraxetan , Z , Zalutumumab , Zatuximab

 

Spice

 Curcumin (turmeric), Super-bio-curcumin

 NSAIDs
Salicylates, Aspirin (acetylsalicylic acid), Diflunisal, Salsalate, Propionic acid derivatives, Ibuprofen[46], Dexibuprofen, Naproxen, Fenoprofen, Ketoprofen, Dexketoprofen, Flurbiprofen, Oxaprozin, Loxoprofen, Acetic acid derivatives, Indomethacin, Tolmetin, Sulindac, Etodolac, Ketorolac, Diclofenac (Safety alert by FDA[47]), Nabumetone (drug itself is non-acidic but the active, principal metabolite has a carboxylic acid group), Enolic acid (Oxicam) derivatives, Piroxicam, Meloxicam, Tenoxicam, Droxicam, Lornoxicam, Isoxicam, Fenamic acid derivatives (Fenamates ), Mefenamic acid, Meclofenamic acid, Flufenamic acid, Tolfenamic acid, Selective COX-2 inhibitors (Coxibs), Celecoxib (FDA alert[48]), Rofecoxib (withdrawn from market[49]), Valdecoxib (withdrawn from market[50]), Parecoxib FDA withdrawn, licenced in the EU, Lumiracoxib TGA cancelled registration, Etoricoxib not FDA approved, licenced in the EU, Firocoxib used in dogs and horses, Sulphonanilides, Nimesulide (systemic preparations are banned by several countries for the potential risk of hepatotoxicity), Others, Licofelone acts by inhibiting LOX (lipooxygenase) & COX and hence known as 5-LOX/COX inhibitor, Lysine clonixinate, Natural, Hyperforin, Figwort

Statins

Lipitor (atorvastatin) (Best in Murtola study), Lescol (fluvastatin), Mevacor (lovastatin), Altoprev 1release), Livalo (pitavastatin), Pravachol (pravastatin), Crestor (rosuvastatin), and Zocor (simvastatin) (Pam's friend). Combination products include: Advicor (lovastatin/niacin extended-release), Simcor (simvastatin/niacin extended-release), and Vytorin (simvastatin/ezetimibe)

Steroids

Hydrocortisone (cortisol), Cortisone, Prednisone, Prednisolone, Methylprednisolone, Dexamethasone, Betamethasone, Triamcinolone, Beclometasone, Fludrocortisone acetate, Deoxycorticosterone acetate (DOCA),  Aldosterone

Bisphosphonates

 Actonel (risedronate), Zometa/Aclasta (Zoledronic acid, Zoledronate), Pamidronate/Fosamax (Alendronate), Bonefos/Clasteon/Loron (Clodronate), also see Xgeva (denosumab)

Oligometastatic disease

Only a few metastases (oligo = small, little, a few)

Imaging

CT or CAT: Computed tomography – using X-rays. Best to view hard body tissues like bone, but by introducing contrast agents into the patient can be used on many types of tissues.

PET: Positron emission tomography – using gamma rays from an agent introduced into the patient. Usually done in a CT machine, it can be thought of as a CT scan with a radionuclide tracer injected.

MRI: Magnetic resonance imaging – using magnetism. Best to view soft body tissues, but by introducing contrast agents into the patient can be used on many types of tissues.
Economic issues: A modern 3,0 Tesla MRI scanner costs more than $2 million, and the specially shielded MRI suite around $500,000 on top. Scans to cover this investment may cost more than other scans, though the cost of newer contrast agents may be a factor in these and other scans as well.

Chemotherapy

Taxotere (docetaxel), Jevtana (Cabazitaxel), Novantrone/DHAD (Mitoxantrone (sometimes spelt mitozantrone))

Flow and scaring

Trental (pentoxifylline) two or three times a day has been shown to reduce scaring after radiation.

Flomax is FDA-approved for two 0.4 mg tabs a day for flow.

Radiopharmaceuticals

Xofigo (Alpharadin, Radium-223 chloride)

Edited by JimJimJimJim
Update, correct Diethylstilbestrol

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