Choosing between Zytiga or Xtandi (Abiraterone or Enzalutamide)

[Admin]

Chalkie asks:

I am now having to choose between Zytiga and Xtandi.
Is there a forum for this?
Any suggestions? 

 

Jim Marshall (not a doctor) said ...
A recent trial for men with metastatic prostate cancer who were no longer responding to ADT alone (mCRPC) showed similar outcomes on both drugs.

So, it appears your doctor could recommend either, unless they are worried about how a particular side effect may affect you personally:

• If you have a health condition that could be made worse by possible seizure or fatigue, your doctor may steer away from Xtandi. 
• If you have a health condition that could be made worse by possible by increased blood pressure, low potassium, or increased liver enzymes, your doctor may steer away from Zytiga.

... end Jim

 

A link to an article on this can be found here:
Abiraterone and Enzalutamide equivalent as first-line therapy in metastatic hormone therapy- resistant prostate cancer

[Chalkie]

Hi Jim

Thanks for your prompt response

I am working through the pros and cons.

 

One thought is that Xtandi is a more advanced approach in that it working on the receptors in Pca rather than androgen deprivation. But concerns about fatigue & seizures are an issue.  Hypertension has been a problem for me in the past but now is well controlled with meds.  It is a dilemma for me but I guess I will get there.    

 

Chalkie