Metabolic syndrome weak in predicting incidence of PCa - hypertension and/or diabetes stronger predictors

[JimmyToowong]

The effects of metabolic conditions on prostate cancer incidence over 15 years of follow-up: Results from the Olmsted County Study

Department of Urology, Department of Environmental Health Sciences and Comprehensive Cancer Center, Department of Epidemiology, University of Michigan, Ann Arbor, MI.

Division of Biomedical Statistics and Informatics Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN; Division of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA.

Study Type - Prognosis (population-based cohort)?Level of Evidence?2a.

Research on the possible role of the metabolic syndrome in the aetiology of prostate cancer has yielded inconsistent results. Combining multiple components of the syndrome into a single variable may obscure the separate and combined effects of these metabolic components on prostate cancer risk. The aim of the present study was to determine if combinations of obesity, hypertension and diabetes influence the development of prostate cancer over 15 years of follow-up.

In 1990, a randomly selected cohort of Caucasian men from Olmsted County, MN, USA, aged 40-79 years, was recruited; 2445 completed a questionnaire that included physician-diagnosed diabetes and hypertension. Anthropometric measures were collected during clinical examination. Biopsy-confirmed prostate cancer was identified from medical records. Proportional hazards regression was used to estimate the effects of these metabolic conditions, both individually and in combination, on the incidence rate of prostate cancer.

Men with hypertension alone or in combination with diabetes were more likely to develop prostate cancer than were men without any of the metabolic conditions. The metabolic syndrome - the presence of all three conditions compared with men with no metabolic components - was only minimally and inversely associated with prostate cancer [hazard ratio (HR): 0.81; 95% confidence interval (CI): 0.20, 3.3] and no monotonic association between the number of metabolic components and prostate cancer was observed.

Our results suggest that it may not be sufficient to treat metabolic conditions as one variable when investigating the aetiology of prostate cancer in Caucasian men. Further research should focus on the separate and combined effects of these metabolic conditions in large samples.

Written by:

Wallner LP, Morgenstern H, McGree ME, Jacobson DJ, St Sauver JL, Jacobsen SJ, Sarma AV. [1]

Reference: BJU Int. 2010 Sep 29. Epub ahead of print.

doi: 10.1111/j.1464-410X.2010.09703.x

PMID: 20880183 Forum: Other prostate cancer topics including radiation Title: Metabolic syndrome weak in predicting incidence of PCa - hypertension and/or diabetes stronger predictors.

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