alanbarlee Posted April 28, 2015 Share Posted April 28, 2015 Hi Folks. Here's an interesting report on MCP - a favorite of Dr Stephen Strum (specialist prostate cancer oncologist (USA). Alan Oral MCP enhances anti-cancer, anti-metastatic effects of radiation therapy in prostate cancer treatment Published on April 22, 2015 at 7:21 AM · Scientists at Tel Aviv Medical Center, Israel, have found that oral modified citrus pectin (MCP) enhances the anti-cancer and anti-metastatic effects of radiation therapy in the treatment of androgen-independent (AI) aggressive prostate cancer cells. Results were presented today at the American Association for Cancer Research (AACR) Annual Meeting 2015. The study, titled, "Combined effect of modified citrus pectin (MCP) and ionizing radiation on viability and metastatic activity of prostate cancer cells," demonstrated that MCP enhanced radiation treatment of prostate cancer by increasing radio-sensitivity of aggressive prostate cancer cells. Previous research demonstrated MCP's anti-cancer actions, including induction of apoptosis, inhibition of proliferation and metastasis, and synergy with chemotherapeutic drugs and botanical compounds. MCP also protects against inflammation and fibrosis, via its binding affinity for the pro-inflammatory protein, galectin-3. However, this is the first study to clearly demonstrate MCP's ability to radio-sensitize aggressive, AI prostate cancer cells. "Radio-resistance is a key contributor to the decreasing effectiveness of radiation treatment for aggressive, androgen-independent prostate cancer. The potential of MCP to increase radio-sensitivity in aggressive prostate cancer is encouraging news for researchers and patients alike," states Dr. Isaac Eliaz, MD, MS, LAc, one of the study's lead investigators. "Furthermore, MCP's ability to protect against inflammation and fibrosis via galectin-3 inhibition helps to minimize fibrotic damage to healthy tissues - a common side effect of radiation treatment." In the study, researchers used cellular viability and clonogenic assays to evaluate the effects of MCP on the viability of AI-prostate cancer cell lines DU-145, PC-3, and CI-1, alone and in combination with radiation treatment. Alone, MCP induced a dose-dependent decrease in cell viability. The combination of MCP and radiation treatment produced synergistic effects against prostate cancer cell lines DU-145 and CI-1, and additive effects against cell line PC-3. Treatment of cells with MCP reduced cell migration by 20% and reduced cell invasion by 40%. These results demonstrate MCP to be an effective radio-sensitizer of AI prostate cancer cells, suggesting that MCP may be used to selectively enhance cytotoxicity and overcome radio-resistance. The MCP used in the study is made from the pith of citrus fruit peels, and modified to a specific molecular weight and structure using a proprietary enzymatic and pH process. Previous research has demonstrated MCP's benefits in a number of cancer types, including breast, prostate, colon and others. MCP is also an effective chelator of toxic metals, as well as a selective immune enhancer shown to activate and increase cytotoxicity of NK cells ex vivo. Source: Better Health Publishing Link to comment Share on other sites More sharing options...
Bruce Kynaston Posted April 29, 2015 Share Posted April 29, 2015 This must commence with an explanation, as I had not completed my response. (I had a power outage so filled in time, and hoped to continue after the power returned, as I had to see the electrician. Then I found I had to do it this way.) The Prof. Advised that as there was no patent to MCP, there were no grants to continue. I tried to encourage PCFA to ask what he needed to continue. No dice! It is great to learn of this new report. I would be interested in hearing of/seeing the full text so I may be able to comment further, as there may be references to Medical Journal articles that give more detail. Bruce. Naturally, I enjoyed hearing of the subject again.u Link to comment Share on other sites More sharing options...
Bruce Kynaston Posted April 29, 2015 Share Posted April 29, 2015 Sorry, but the original effort must have 'evaporated' but I shall take time later to fill out the lost commencement, to make sense of the 'first' reply, as seen. Bruce. Link to comment Share on other sites More sharing options...
Bruce Kynaston Posted April 30, 2015 Share Posted April 30, 2015 To continue this saga, that is to get back to where I wanted to commence, I report. about 10 years ago I came across a report on MCP. A Urology Professor at Ann Arbor University in Michigan had shown that in mice implanted with human PCa cells, those on a diet including MCP had fewer metastases than the controls. I corresponded to ask where his research had gone since that report. He replied, that as there was no patent covering MCP, there was no money available to help. It would have been good to know what sort of dose could be recommended. Bruce. Link to comment Share on other sites More sharing options...
Paul Edwards Posted April 30, 2015 Share Posted April 30, 2015 Alan, you mentioned that Modified Citrus Pectin was a favourite of Stephen Strum. Does Strum answer Bruce's question about dosage of MCP? Link to comment Share on other sites More sharing options...
Bruce Kynaston Posted April 30, 2015 Share Posted April 30, 2015 I have sent an email to Stephen to the address he gave me when he attended the first of two great international meetings on PCa at the Gold Coast maybe 10 years ago, or a few less. If he did make a mention, I might hear it from him. Bruce. Link to comment Share on other sites More sharing options...
alanbarlee Posted May 1, 2015 Author Share Posted May 1, 2015 Hi Bruce/Paul, MCP is made by/for Allergy Research Group, (which has a website of the same name.com). Dr Pienta was the principal research scientist. The product is apparently made by hydrolysing the complex polysaccharide citrus pectin, presumably to increase absorbtion in the gut. The suggested dose as a dietary supplement is 5 g (a rounded teaspoon) mixed with water, juice or some other liquid, one to three times daily. Alan Link to comment Share on other sites More sharing options...
Paul Edwards Posted May 1, 2015 Share Posted May 1, 2015 I think that Dr Pienta who carried out the initial research on MCP is the Urology Professor at Ann Arbor University in Michigan to whom Bruce refers. The MCP made by Allergy Research Group claims to be "prepared to the standards set forth by Dr. Pienta, who has done most of the research on Modified Citrus Pectin". Dr. Isaac Eliaz is one of the lead investigators in the recent study at Tel Aviv Medical Centre on MCP. The Life Extension Foundation website claims that " only one brand of commercially available MCP — Pecta-Sol® — meets the chemical specifications used in all of the scientific studies. It also is the only brand that has been used and validated in clinical trials." And who is the distributor of Pecta-Sol®? Why it’s Dr. Isaac Eliaz, who designed Pecta-Sol® and conducted several of the studies on its use! One of Dr Eliaz’s studies has found that Pecta-Sol® MCP works better for prostate cancer if it is combined with a novel integrative polybotanical compound called ProstaCaid. Now I wonder who makes ProstaCaid? Link to comment Share on other sites More sharing options...
Bruce Kynaston Posted May 5, 2015 Share Posted May 5, 2015 Hi Bruce/Paul, MCP is made by/for Allergy Research Group, (which has a website of the same name.com). Dr Pienta was the principal research scientist. The product is apparently made by hydrolysing the complex polysaccharide citrus pectin, presumably to increase absorbtion in the gut. The suggested dose as a dietary supplement is 5 g (a rounded teaspoon) mixed with water, juice or some other liquid, one to three times daily. Alan I went to the website and found, as below, that if one dose was taken 3 times per day, one container costing US$117.17 would last a month. Our $1 buys somewhere in the 80 UScents.Not inexpensive. For your information. Bruce. Modified Citrus Pectin Powder 16 oz #71990 Home > Specialty Products Modified Citrus Pectin Powder 16 oz MSRP: $117.17 Item #: 71990 Natural Standard Monograph Authorized Users, please Log In to order Not Registered? Register Here Same as Item #72060, in a more economical powdered form. Modified citrus pectin is different from other pectin because of the way it is prepared. It is modified by a proprietary process, which reduces the molecular weight of the pectin molecule. Average molecular weight: 30kD; pH: 6.0-7.2; Methoxylation: not more than 5%. Suggested Use: As a dietary supplement, 5 to 15 grams daily; dissolve one rounded teaspoon (approx. 5 g) of powder in water, juice or other liquid and drink one to three times daily, or as directed by a healthcare practitioner. NOTE: For easier mixing, place Modified Citrus Pectin Powder in a jar or shaker with desired liquid and shake. CAUTION: Those on a sodium-restricted diet should consult their healthcare practitioner before use. Serving Size 1 teaspoon (5g) Servings per container 90 Amount per serving: Calories 20 Sodium 295 mg Total Carbohydrates 5 g Dietary Fiber 3 g Sugars 2 g Modified Citrus Pectin 5 g This nutrient is of the highest quality and purity obtainable, and does not contain preservatives, diluents, or artificial additives. Keep in a cool, dry place, tightly capped. *This statement has not been evaluated by the U.S. Food and Drug administration. The product is not intended to diagnose, treat, cure, or prevent any disease. Link to comment Share on other sites More sharing options...
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