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Lutetium 177 (Lu-177) - New treatment trialled


Paul Edwards

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Paul Edwards

Xofigo (radium 223) has changed the treatment of prostate cancer metastatic to bone.  Xofigo is chemically similar to calcium, so tissues that uptake calcium uptake radium as well. That means principally bone, especially in highly metabolically active sites like bone metastases.

 

Lutetium-177 (Lu-177) is a radioactive substance which scientists have attached to an antibody found on the surface of at least 95 percent of prostate cancer cells and called prostate surface membrane antigen (PSMA). 

 

Unlike Xofigo, which only attaches to bone metastases, Lu-177-anti-PSMA attaches to any metastasis — bone, lymph node or visceral.   It can potentially treat systemic micrometastases as well.

 

Click on the link to read an interesting article in the New Prostate Cancer Infolink.

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Paul Edwards

Researchers are looking at another interesting use of PSMA antibodies.

 

Instead of linking a radioactive tracer to PSMA antibodies,  the next step will be to link the PSMA antibodies to a light-emitting molecule called a fluorophore.  The fluorophore will be activated  at the time of surgery to light up cancer cells so the surgeon can see the extent of the cancer and can ensure that he has removed all of the cancer.  The surgeon would also be able to see whether lymph nodes were affected and needed to be removed.

 

Some amazing developments are happening in the treatment of prostate cancer!

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  • 1 year later...
Paul Edwards

There have now been further clinical trials in Germany with Lutetium-177

 

The New Prostate Cancer Infolink has an update,  Click on this link to read the article.

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