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  1. This may be a drug to watch in the future. Seviteronel (VT-464) is a once-daily oral therapeutic given without prednisone. Seviteronel selectively inhibits CYP17 lyase, a target of abiraterone, and has unique blocking effects on the androgen receptor (AR), the target of enzalutamide. There is a growing body of preclinical and clinical evidence that shows that some abiraterone- or enzalutamide-resistant patients will respond to seviteronel treatment. Currently there are phase II clinical trials of seviteronel in the US and Europe. At the moment there are not any clinica
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