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  1. I was diagnosed with an aggressive prostate cancer (Gleeson 10) in June 2017. Following the diagnosis I was immediately put on ADT using Zolodex and have been on it continuously since. I have also undergone 8 weeks of radiation therapy. To date treatment has been successful and I have had a PSA level of 0.02 for about the last 18 months. My problem is that I have uncontrollable mood swings in which I become quite angry and short tempered. I also have thoughts that have no basis in reality during these swings which is putting considerable pressure on my family. My trouble is th
  2. This video today is about weight training for men on hormone therapy for prostate cancer. Hormone therapy is also called 'Androgen Deprivation Therapy' (ADT) because it robs a man of androgens. The main androgen is testosterone. Androgens fuel prostate cancer. And a reminder that we have a few videos of our own on the JimJimJimJim channel: https://www.youtube.com/jimjimjimjim/videos The Prostate Cancer Research Institute (PCRI) is an important source of information for about prostate cancer for patients, families, and the medical community. A
  3. alanbarlee

    Hot flushes from ADT

    Margaret asked about hot flushes at our September 2019 call-in conference. Here's some up-to-date information from one our leading urologists. Hot flushes (extracts from ACCP Consensus Conference 2019 - UroToday) The important topic of hot flushes caused by androgen deprivation therapy (ADT) was discussed by Dr. Frydenberg (Melbourne urologist). Hot flushes are defined as a subjective feeling of warmth in the upper torso, followed by excessive perspiration. Approximately 80-90% of men on ADT endure hot flushes, with 27% reporting them as the most trou
  4. Kezza2

    Now for Docetaxel

    Well gentlemen, The time has come. I was on abiraterone + apelutimide trial for two years until that failed, and swapped to enzalutimide (Xtandi) but that only lasted three months, and now my PSA has more than doubled from 17 to 38 in 6 weeks, so it seems that docetaxel is next on the list. Having not had docetaxel previously I am not a candidate for the Lu177 trial unfortunately, so I am scheduled to start docetaxel in two weeks. I would appreciate any words of wisdom from the wise who have already been through this on side effects and how to avoid or minimise them, and wh
  5. AnCan 5th Monday Plenary .... Cancer, Sleep & Dreams Tuesday,Jan 30 - Brisbane: Tuesday 30 January 11AM Sydney: Tuesday 30 January Noon Adelaide: Tuesday 30 January 11:30AM Perth: Tuesday 30 January 9AM Joining instructions below pdf attached Hello Friends - One subject we all experience, often in a highly compromised fashion after diagnosis, is SLEEP! It rarely gets addressed ... we just take it for granted even though we spend a third of our lives trying to practice it. How many of you have raised sleep is
  6. "TAPS stands for “taxane acute pain syndrome”. It is a recognized side effect of treatment with taxanes like docetaxel. It is usually characterized by muscular pain (myalgia) and joint pain (arthralgia) that starts about 24 to 48 hours after taxane treatment and then lasts for up to about 7 days. However, relatively little is known about its incidence and predisposing factors in men with prostate cancer who are being treated with taxane-based chemotherapy.....................
  7. " In what seems to be a first, study researchers are saying that they might have uncovered a link between ADT and Alzheimer’s. Their study is small and preliminary and it does not prove a cause-and-effect relationship, but merely shows an association between ADT and Alzheimer’s disease." Click here to read more.
  8. Joel Nowak of Malecare reports on an abstract presented at the 2016 American Society of Clinical Oncology (ASCO) Scientific Meeting about how abiraterone (brand name Zytiga) and enzalutamide (brand name Xtandi) may cause cognitive impairment and mood changes. Interestingly the research showed that these side effects were more prevalent with enzalutamide than with abiraterone. Click on this link to read the Malecare report..
  9. Having incurable cancer has caused Larry Axmaker to adjust his definition of "quality of life". Click here to read about how Larry defines "quality of life"
  10. One of the drugs used in androgen deprivation therapy is Firmagon (degarelix). Firmagon requires a monthly injection. There can be severe pain at the site of the injection (caused by bruising and rashes which can last for 3-4 days each month). This post has been updated with additional suggestions about how to miminise the pain from a Firmagon injection.
  11. We are all familiar with the concept of intermittent ADT as opposed to continuous ADT. Now researchers are investigating the concept of intermittent chemotherapy as opposed to continuous chemotherapy. If certain criteria are met, there will a break in the chemotherapy treatment and the patient will have a “drug holiday”. In theory intermittent chemotherapy may serve 2 purposes. First, with less constant exposure to the drug, this may potentially delay the development of taxane-refractory disease. Second, breaks in therapy or “drug holidays” ma
  12. Peripheral neuropathy is a common side effect of chemotherapy treatment for prostate cancer. Patients who suffer from this condition have damage to their peripheral nerves and experience weakness, numbness and pain usually in their hands or feet and occasionally in other areas of the body. Researchers at the Moffatt Cancer Center at Tampa, Florida have found that genetic alterations in the VAC14 gene are associated with an increased risk of docetaxel-induced peripheral neuropathy in prostate cancer patients. This discovery may help scientists to understand what causes
  13. Depression resulting from Androgen Deprivation Therapy is a completely under-recognized phenomenon, according to a recent article. Click on this link to read the article. Beyond Blue 1300 22 4636 and Lifeline 13 11 14 provide support for depression.
  14. Paul Edwards

    Help! - Hot flushes

    One of our members has just started ADT and complains "These hot flushes are still coming every 30 minutes 24/7. It's nearly 4am and just been woken up again covered in sweat!" What worked for you when you were battling with hot flushes?
  15. ADT carries with it a heightened risk of depression as well as cognitive effects. The cognitive impact, though, is neither well defined nor consistent. The data collectively suggest that the negative impact of ADT on patients directly (and on their intimate partners indirectly) are greater for younger than older men. Across the array of adverse effects, physical exercise appears to have the greatest potential to address the psychological effects of ADT, both in men who are receiving ADT and in their partners. Donovan KA, Walker LM, Wassersug RJ, Thompson LM, Robinson JW. 2015. Psyc
  16. Chemotherapy can cause peripheral neuropathy (damage to your peripheral nerves). Peripheral neuropathy often causes weakness, numbness and pain, usually in your hands and feet. A study of female cancer survivors found that almost half experience chemotherapy-induced peripheral neuropathy symptoms years after completing their cancer treatment. These symptoms were associated with impacts including reduced mobility and significantly increased risk of falls. The results were presented at the American Society of Clinical Oncology (ASCO) Cancer Survivorship Symposium held in San Francisco
  17. Researchers asked prostate cancer patients to fill in an online questionnaire on their mood in relation to the prostate cancer treatments they had received. Their results showed that, compared to patients not on ADT, ADT does indeed negatively affect the mood of men, most notably increasing their sense of fatigue and decreasing their sense of vigor. The authors also asked partners of patients to rate the patients’ moods. The partners reported similar declines in the patient’s mood that the patients reported, but to a greater degree than the patients themselves. Often our partners know us
  18. A retrospective study of nearly 17,000 patients has suggested that androgen-deprivation therapy (ADT) is associated with an increased risk for the future development of Alzheimer's disease in men with prostate cancer,. Click here to read a report in the New Prostate Cancer Infolink about the study. Researchers can’t prove a direct cause-and-effect link between ADT and Alzheimer’s in an observational study like this. Some other unknown variable might be influencing the results........ Given that it’s a first-time association in a retrospective analysis, this study hel
  19. According to this WebMD paper, for patients prescribed the anticoagulant (blood thinner) warfarin there is a long list of medications that both patient and treating doctor must be aware as causing severe to serious to moderate side effects: http://tinyurl.com/qcafmkw Interesting, among them, are several that prostate cancer patients are prescribed including NSAIDs (identified here http://tinyurl.com/nhtjyvh), enzalutamide, corticosteroids (thus prednisone if prescribed abiraterone), acetaminophen, and several others. If you're a patient prescribed warfarin and also pres
  20. I got asked by someone about handling the side effects from chemo. Here are some suggestions. Click on this link for some suggestions from the Cancer Council. Click on this link for a research study which looked at the evidence for what works and what doesn’t. Do any members have other suggestions of what worked for them?
  21. Paul Edwards

    Xofigo Update

    The US Federal Drugs Administration approved the use of Radium 223 (Brand name Xofigo also called Alpharadin) two years ago. The well-known US prostate oncologist Dr Mark Scholz gives an update on the experience of his clinic in using the drug. Click on this link to read his article. Xofigo is not yet available in Australia on the PBS
  22. A good video by the Prostate Cancer Canada Network Calgary. Psychologists from the Tom Baker Cancer Centre in Calgary Canada, Lauren M. Walker and John W. Robinson, share a talk the context of when Androgen Deprivation Therapy, or ADT, is used for treatment. They also talk about the studies and work they've done on the treatment, the side effects and ways to deal with them.
  23. An interesting article about a presentation on hormone therapy made by Australian researchers to this year's American Society of Clinical Oncology (ASCO) Annual Meeting. Click on this link to read it.
  24. The Prostate Cancer Foundation of Australia has posted a video on YouTube of the following talk on Radiation Therapy for Prostate Cancer given by radiation oncologist A/Prof Michael Izard at Sydney Adventist Hospital on 22 June 2015 .
  25. Paul Edwards

    ADT affects the brain

    Cognitive impairment can occur in cancer patients who are treated with a variety of therapies, including radiation therapy, hormone therapy, and chemotherapy. After chemotherapy treatment it is commonly called "chemo brain." Signs of cognitive impairment include forgetfulness, inability to concentrate, problems recalling information, trouble multi-tasking and becoming slower at processing information. The number of people who experience cognitive problems following cancer therapy is broad, with an estimated range of 15 to 70 percent. There have been several studies analyzing this side e
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