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  1. Jim Marshall (not a doctor) said ... In this video Prostate Cancer Research Institute Executive Director Mark Scholz talks about a clinical trial for men who are metastatic and have rising psa on hormone therapy. The trial is testing whether adding the PARP inhibitor Lynparza (olaparib) to the super-hormone Zytiga (abiraterone) increases its effectiveness. You can find out about the clinical trial at: https://clinicaltrials.gov/ct2/show/study/NCT03732820?show_locs=Y#locn Details there include: inclusion details (things you need to get into the trial); exclusion details (what will keep you out of the trial); and locations. Australian locations include: Box Hill, Australia, 3128 Darlinghurst, Australia, 2010 Greenslopes, Australia, 4120 Herston, Australia, 4029 Kingswood, Australia, 2747 Kurralta Park, Australia, 5037 St Albans, Australia, 3021 Waratah, Australia, 2298 As always, ask your doctor if you think this might be for you. ... end Jim
  2. An interesting account by Professor Michael Hofman at the Advanced Prostate Cancer Consensus Conference in Basel, Switzerland recently. He speaks of the Lutetium-177 (Lu-177) treatment his team and others have done or are planning: https://www.urotoday.com/video-lectures/apccc-2019-conference/video/1467-players-brightcove-net2019-09-10-14-49-08.html Below the video is a full transcript - all the words Professor Hofman says in the video. Thanks to Nev and Lorraine
  3. Hi guys Is anyone enrolled in the Profound trial or have any knowledge of this? The official purpose of the trial is: The purpose of this study is to evaluate the efficacy and safety of olaparib versus enzalutamide or abiraterone acetate in subjects with metastatic castration-resistant prostate cancer who have failed prior treatment with a new hormonal agent and have homologous recombination repair gene mutations This trial has been enrolling in Australia over the last 6 months or so. I have germline BRCA2 mutation which has probably caused my mCRPC disease. I have been through my options with enzalutamide and abiraterone and have had Docetaxel. Currently looking at commencing a platinum based chemotherapy treatment using Carboplatin, normally used in Ovarian cancer. Any thoughts/experiences around Profound and/or the BRCA mutation and treatment experiences would be very welcome. Thanks and best wishes to you all Martin
  4. The United States Food and Drug Administration (FDA) has classified Olaparib (brand name Lynparza) as a Breakthrough Therapy for men with metastatic castrate-resistant prostate cancer with DNA repair defects in their tumours. This means the application to have Olaparib approved by the FDA for prostate cancer will be fast tracked and it is likely that Olaparib will be approved later this year. The FDA's decision to recognise Olaparib as a Breakthrough Therapy was reported in ONCLive
  5. Olabarib is a drug which the United States Food and Drug Administration (FDA) has approved for the treatment of ovarian cancer patients with mutations of the BRCA1and BRCA2 genes, which play key roles in DNA damage repair. Mutations in these genes have been linked with the development and progression of many tumour types, including prostate cancer. A clinical study has shown that Olaparib is highly effective at treating men with DNA repair defects in their tumours. About 30% of men with prostate cancer have DNA repair defects in their tumours - either they have inherited mutations in the BRCA1 and BRCA2 genes or, as their cancer has progressed, their tumours have developed defects in DNA repair. Further clinical trials will be necessary before Olaparib will be generally available for prostate cancer patients. Because the FDA has already approved Olaparib for the treatment of ovarian cancer, it is likely to speed up the approval process to use Olaparib for prostate cancer. Click on this link for further information about this research. [Some of our members are aware that they have the BRCA1 and BRCA2 genes - this is very exciting news for them. One of the men that I met at the PCRI conference in Los Angeles last month was being treated with Olaparib.]
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