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  1. Jim Marshall (not a doctor) said ... In this video Prostate Cancer Research Institute Executive Director Mark Scholz talks about a clinical trial for men who are metastatic and have rising psa on hormone therapy. The trial is testing whether adding the PARP inhibitor Lynparza (olaparib) to the super-hormone Zytiga (abiraterone) increases its effectiveness. You can find out about the clinical trial at: https://clinicaltrials.gov/ct2/show/study/NCT03732820?show_locs=Y#locn Details there include: inclusion details (things you need to get into the trial);
  2. An interesting account by Professor Michael Hofman at the Advanced Prostate Cancer Consensus Conference in Basel, Switzerland recently. He speaks of the Lutetium-177 (Lu-177) treatment his team and others have done or are planning: https://www.urotoday.com/video-lectures/apccc-2019-conference/video/1467-players-brightcove-net2019-09-10-14-49-08.html Below the video is a full transcript - all the words Professor Hofman says in the video. Thanks to Nev and Lorraine
  3. Hi guys Is anyone enrolled in the Profound trial or have any knowledge of this? The official purpose of the trial is: The purpose of this study is to evaluate the efficacy and safety of olaparib versus enzalutamide or abiraterone acetate in subjects with metastatic castration-resistant prostate cancer who have failed prior treatment with a new hormonal agent and have homologous recombination repair gene mutations This trial has been enrolling in Australia over the last 6 months or so. I have germline BRCA2 mutation which has probably caused my mCRPC disease. I have bee
  4. The United States Food and Drug Administration (FDA) has classified Olaparib (brand name Lynparza) as a Breakthrough Therapy for men with metastatic castrate-resistant prostate cancer with DNA repair defects in their tumours. This means the application to have Olaparib approved by the FDA for prostate cancer will be fast tracked and it is likely that Olaparib will be approved later this year. The FDA's decision to recognise Olaparib as a Breakthrough Therapy was reported in ONCLive
  5. Olabarib is a drug which the United States Food and Drug Administration (FDA) has approved for the treatment of ovarian cancer patients with mutations of the BRCA1and BRCA2 genes, which play key roles in DNA damage repair. Mutations in these genes have been linked with the development and progression of many tumour types, including prostate cancer. A clinical study has shown that Olaparib is highly effective at treating men with DNA repair defects in their tumours. About 30% of men with prostate cancer have DNA repair defects in their tumours - either they have inherited mutations in th
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